Succinylation
Addition of a succinyl group to a lysine group of a protein
In biochemistry, succinylation is a posttranslational modification where a succinyl group (−CO−CH2−CH2−CO2H) is added to a lysine residue of a protein molecule. This modification is found in many proteins, including histones.[1] The potential role of succinylation is under investigation, but as addition of succinyl group changes lysine's charge from +1 to −1 (at physiological pH) and introduces a relatively large structural moiety (100 Da), bigger than acetylation (42 Da) or methylation (14 Da), it is expected to lead to more significant changes in protein structure and function.[2]
By analogy to acetylation, it has been suggested that succinyl-CoA is the cofactor of enzyme-mediated lysine succinylation.
References
- ^ Xie, Z.; Dai, J.; Dai, L.; Tan, M.; Cheng, Z.; Wu, Y.; Boeke, J. D.; Zhao, Y. (2012). "Lysine succinylation and lysine malonylation in histones". Molecular & Cellular Proteomics. 11 (5): 100–7. doi:10.1074/mcp.M111.015875. PMC 3418837. PMID 22389435.
- ^ Zhang, Z.; Tan, M.; Xie, Z.; Dai, L.; Chen, Y.; Zhao, Y. (2010). "Identification of lysine succinylation as a new post-translational modification". Nature Chemical Biology. 7 (1): 58–63. doi:10.1038/nchembio.495. PMC 3065206. PMID 21151122.
External links
- Succinylation, Yet A Novel PTM Pathway for Biological Regulation, But Ready to Be Investigated
- Succinyl group at ChEBI
- The dawn of succinylation: a posttranslational modification.
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Protein primary structure and posttranslational modifications
- Peptide bond
- Protein biosynthesis
- Proteolysis
- Racemization
- N–O acyl shift
- Acetylation
- Carbamylation
- Formylation
- Glycation
- Methylation
- Myristoylation (Gly)
- Amidation
- Glycosyl phosphatidylinositol (GPI)
- O-methylation
- Detyrosination
| Serine/Threonine | |
|---|---|
| Tyrosine | |
| Cysteine | |
| Aspartate | |
| Glutamate | |
| Asparagine | |
| Glutamine | |
| Lysine |
|
| Arginine | |
| Proline | |
| Histidine |
|
| Tryptophan |
| Cysteine–Cysteine | |
|---|---|
| Methionine–Hydroxylysine | |
| Lysine–Tyrosine |
|
| Tryptophan–Tryptophan |
| Serine–Tyrosine–Glycine |
|
|---|---|
| Histidine–Tyrosine–Glycine |
|
| Alanine–Serine–Glycine |
| Allysine–Allysine–Allysine–Lysine |
|---|
