UBE1L

Protein-coding gene in the species Homo sapiens
UBA7
Identifiers
AliasesUBA7, D8, UBA1B, UBE1L, UBE2, ubiquitin like modifier activating enzyme 7, UBE7
External IDsOMIM: 191325; MGI: 1349462; HomoloGene: 2502; GeneCards: UBA7; OMA:UBA7 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for UBA7
Genomic location for UBA7
Band3p21.31Start49,805,209 bp[1]
End49,813,953 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for UBA7
Genomic location for UBA7
Band9 F1|9 59.07 cMStart107,852,704 bp[2]
End107,861,259 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • spleen

  • right uterine tube

  • lymph node

  • appendix

  • duodenum

  • gallbladder

  • right lobe of thyroid gland

  • right coronary artery

  • left lobe of thyroid gland

  • rectum
Top expressed in
  • spleen

  • blood

  • duodenum

  • thymus

  • submandibular gland

  • jejunum

  • intestinal villus

  • ileum

  • bone marrow

  • stomach
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • ATP binding
  • ISG15 activating enzyme activity
  • nucleotide binding
  • ubiquitin-like modifier activating enzyme activity
  • ligase activity
  • protein binding
  • ubiquitin-protein transferase activity
  • ubiquitin activating enzyme activity
Cellular component
  • nucleoplasm
  • cytosol
  • cytoplasm
  • nucleus
Biological process
  • negative regulation of type I interferon production
  • ISG15-protein conjugation
  • protein ubiquitination
  • modification-dependent protein catabolic process
  • ubiquitin-dependent protein catabolic process
  • cellular response to DNA damage stimulus
  • protein modification by small protein conjugation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7318

74153

Ensembl

ENSG00000182179

ENSMUSG00000032596

UniProt

P41226

n/a

RefSeq (mRNA)

NM_003335

NM_023738

RefSeq (protein)

NP_003326

n/a

Location (UCSC)Chr 3: 49.81 – 49.81 MbChr 9: 107.85 – 107.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ubiquitin-like modifier-activating enzyme 7 is a protein that in humans is encoded by the UBA7 gene.[5][6]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000182179 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032596 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kok K, Hofstra R, Pilz A, van den Berg A, Terpstra P, Buys CH, Carritt B (Aug 1993). "A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme". Proc Natl Acad Sci U S A. 90 (13): 6071–5. Bibcode:1993PNAS...90.6071K. doi:10.1073/pnas.90.13.6071. PMC 46869. PMID 8327486.
  6. ^ a b "Entrez Gene: UBE1L ubiquitin-activating enzyme E1-like".

Further reading

  • Carritt B, Kok K, van den Berg A, et al. (1992). "A gene from human chromosome region 3p21 with reduced expression in small cell lung cancer". Cancer Res. 52 (6): 1536–41. PMID 1311632.
  • Kok K, Van den Berg A, Veldhuis PM, et al. (1995). "The genomic structure of the human UBE1L gene". Gene Expr. 4 (3): 163–75. PMC 6134375. PMID 7734949.
  • McLaughlin PM, Helfrich W, Kok K, et al. (2000). "The ubiquitin-activating enzyme E1-like protein in lung cancer cell lines". Int. J. Cancer. 85 (6): 871–6. doi:10.1002/(SICI)1097-0215(20000315)85:6<871::AID-IJC22>3.0.CO;2-O. PMID 10709110.
  • Yuan W, Krug RM (2001). "Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein". EMBO J. 20 (3): 362–71. doi:10.1093/emboj/20.3.362. PMC 133459. PMID 11157743.
  • Kitareewan S, Pitha-Rowe I, Sekula D, et al. (2002). "UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia". Proc. Natl. Acad. Sci. U.S.A. 99 (6): 3806–11. Bibcode:2002PNAS...99.3806K. doi:10.1073/pnas.052011299. PMC 122605. PMID 11891284.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
  • Pitha-Rowe I, Hassel BA, Dmitrovsky E (2004). "Involvement of UBE1L in ISG15 conjugation during retinoid-induced differentiation of acute promyelocytic leukemia". J. Biol. Chem. 279 (18): 18178–87. doi:10.1074/jbc.M309259200. PMID 14976209.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Lenschow DJ, Giannakopoulos NV, Gunn LJ, et al. (2006). "Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo". J. Virol. 79 (22): 13974–83. doi:10.1128/JVI.79.22.13974-13983.2005. PMC 1280211. PMID 16254333.
  • Takeuchi T, Iwahara S, Saeki Y, et al. (2005). "Link between the Ubiquitin Conjugation System and the ISG15 Conjugation System: ISG15 Conjugation to the UbcH6 Ubiquitin E2 Enzyme". J. Biochem. 138 (6): 711–9. doi:10.1093/jb/mvi172. PMID 16428300.


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