UBE2O

Protein-coding gene in the species Homo sapiens
UBE2O
Identifiers
AliasesUBE2O, E2-230K, ubiquitin conjugating enzyme E2 O
External IDsOMIM: 617649 MGI: 2444266 HomoloGene: 11113 GeneCards: UBE2O
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for UBE2O
Genomic location for UBE2O
Band17q25.1Start76,389,456 bp[1]
End76,453,152 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for UBE2O
Genomic location for UBE2O
Band11|11 E2Start116,428,566 bp[2]
End116,472,273 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • prefrontal cortex

  • gastrocnemius muscle

  • Brodmann area 9

  • ganglionic eminence

  • stromal cell of endometrium

  • islet of Langerhans

  • right lobe of thyroid gland

  • cingulate gyrus

  • sural nerve

  • bone marrow cells
Top expressed in
  • blood

  • superior frontal gyrus

  • entorhinal cortex

  • lens

  • primary motor cortex

  • ventromedial nucleus

  • medulla oblongata

  • superior colliculus

  • cerebellar cortex

  • cingulate gyrus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • nucleotide binding
  • protein binding
  • ATP binding
  • ubiquitin conjugating enzyme activity
  • ubiquitin protein ligase binding
  • ubiquitin protein ligase activity
  • ubiquitin-protein transferase activity
  • RNA binding
Cellular component
  • cytoplasm
  • nucleus
  • cytosol
  • nuclear body
Biological process
  • positive regulation of BMP signaling pathway
  • protein K63-linked ubiquitination
  • retrograde transport, endosome to Golgi
  • protein monoubiquitination
  • protein ubiquitination
  • transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

63893

217342

Ensembl

ENSG00000175931

ENSMUSG00000020802

UniProt

Q9C0C9

Q6ZPJ3

RefSeq (mRNA)

NM_022066

NM_173755

RefSeq (protein)

NP_071349

NP_776116

Location (UCSC)Chr 17: 76.39 – 76.45 MbChr 11: 116.43 – 116.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ubiquitin-conjugating enzyme E2 O is a protein that in humans is encoded by the UBE2O gene.[5][6][7]

UBE2O functions during terminal erythroid differentiation to eliminate generic cellular components in parallel with abundant synthesis of hemoglobin.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000175931 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020802 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Yokota T, Nagai H, Harada H, Mine N, Terada Y, Fujiwara H, Yabe A, Miyazaki K, Emi M (Apr 2001). "Identification, tissue expression, and chromosomal position of a novel gene encoding human ubiquitin-conjugating enzyme E2-230k". Gene. 267 (1): 95–100. doi:10.1016/S0378-1119(01)00407-3. PMID 11311559.
  6. ^ Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (Feb 2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
  7. ^ "Entrez Gene: UBE2O ubiquitin-conjugating enzyme E2O".
  8. ^ Nguyen AT, Prado MA, et al. (2017). "UBE2O remodels the proteome during terminal erythroid differentiation". Science. 357 (6350): eaan0218. doi:10.1126/science.aan0218. PMC 5812729. PMID 28774900.

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Tomsig JL, Snyder SL, Creutz CE (2003). "Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif". J. Biol. Chem. 278 (12): 10048–54. doi:10.1074/jbc.M212632200. PMID 12522145.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin". J. Steroid Biochem. Mol. Biol. 94 (1–3): 203–8. doi:10.1016/j.jsbmb.2005.01.007. PMID 15862967. S2CID 9746088.
  • v
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Chaperones/
protein folding
Heat shock proteins/
Chaperonins
Other
Protein targetingUbiquitin
(ubiquitylation)Ubiquitin-like proteins
(UBL)
SUMO protein
(SUMOylation)
  • E1 SUMO-activating enzyme
  • E2 SUMO-conjugating enzyme
Other


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