Methylprednisolone suleptanate

Chemical compound
Methylprednisolone suleptanate
Clinical data
Trade namesMedrosol, Promedrol
Other namesPNU-67590A; U-67590A; Methylprednisolone 21-(8-(methyl-(2-sulfoethyl)amino)-1,8-dioxooctanoate); 11β,17α-Dihydroxy-6α-methyl-21-((8-(methyl(2-sulfoethyl)amino)-1,8-dioxooctyl)oxy)pregna-1,4-diene-3,20-dione
Routes of
administration		Intravenous administration
Drug classCorticosteroid; Glucocorticoid
Identifiers
  • 2-[[8-[2-[(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-6,10,13-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-8-oxooctanoyl]-methylamino]ethanesulfonic acid
CAS Number
  • 121807-10-1
PubChem CID
  • 56068
ChemSpider
  • 50613
UNII
  • 3O5T2NJE2D
ChEBI
  • CHEBI:135864
ChEMBL
  • ChEMBL1697783
CompTox Dashboard (EPA)
  • DTXSID7023304 Edit this at Wikidata
Chemical and physical data
FormulaC33H49NO10S
Molar mass651.81 g·mol−1
3D model (JSmol)
  • Interactive image
  • C[C@H]1C[C@H]2[C@@H]3CC[C@@]([C@]3(C[C@@H]([C@@H]2[C@@]4(C1=CC(=O)C=C4)C)O)C)(C(=O)COC(=O)CCCCCCC(=O)N(C)CCS(=O)(=O)O)O
InChI
  • InChI=1S/C33H49NO10S/c1-21-17-23-24-12-14-33(40,32(24,3)19-26(36)30(23)31(2)13-11-22(35)18-25(21)31)27(37)20-44-29(39)10-8-6-5-7-9-28(38)34(4)15-16-45(41,42)43/h11,13,18,21,23-24,26,30,36,40H,5-10,12,14-17,19-20H2,1-4H3,(H,41,42,43)/t21-,23-,24-,26-,30+,31-,32-,33-/m0/s1
  • Key:PSCNNGGPKIBAHB-WFVOKNHCSA-N

Methylprednisolone suleptanate, sold under the brand names Medrosol and Promedrol, is a synthetic glucocorticoid corticosteroid and a corticosteroid ester—specifically, the C21 suleptanate 21-(8-(methyl-(2-sulfoethyl)amino)-1,8-dioxooctanoate) ester of methylprednisolone.[1][2] It acts as a prodrug of methylprednisolone.[3] Methylprednisolone suleptanate was developed as an improved alternative to methylprednisolone acetate (Depo-Medrol) with greater water solubility for use by intravenous administration.[3]

See also

References

  1. ^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 811–. ISBN 978-1-4757-2085-3.
  2. ^ Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 675–. ISBN 978-3-88763-075-1.
  3. ^ a b Ferry JJ, Della-Coletta AA, Weber DJ, VanderLugt JT (November 1994). "Pilot study of the pharmacokinetics of methylprednisolone after single and multiple intravenous doses of methylprednisolone sodium succinate and methylprednisolone suleptanate to healthy volunteers". J Clin Pharmacol. 34 (11): 1109–15. doi:10.1002/j.1552-4604.1994.tb01988.x. PMID 7876403. S2CID 40533592.

External links

  • Methylprednisolone suleptanate - AdisInsight
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Glucocorticoids
Natural
Synthetic
AntiglucocorticoidsSynthesis modifiers
See also
Glucocorticoid receptor modulators
Mineralocorticoids and antimineralocorticoids
List of corticosteroids
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GRTooltip Glucocorticoid receptor
Agonists
  • Nonsteroidal glucocorticoids: AZD-5423
  • GSK-9027
Mixed
(SEGRMsTooltip Selective glucocorticoid receptor agonists)
Antagonists
Others
  • Antisense oligonucleotides: IONIS-GCCRRx (ISIS-426115)
See also
Receptor/signaling modulators
Glucocorticoids and antiglucocorticoids
Mineralocorticoid receptor modulators
List of corticosteroids


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