Diflorasone diacetate
Chemical compound and topical steroid
- US DailyMed: Diflorasone
administration
- D07AC10 (WHO)
- US: ℞-only
- [17-(2-Acetyloxyacetyl)- 6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16- octahydrocyclopenta[a]phenanthren-17-yl] acetate
- 2557-49-5
N
- 71414
- 7068
- DB00223
Y
- 64504 Y
- T2DHJ9645W
- D01327 Y
- CHEBI:31483 Y
- ChEMBL1201380 N
- DTXSID8045646
InChI
- InChI=1S/C26H32F2O7/c1-13-8-17-18-10-20(27)19-9-16(31)6-7-23(19,4)25(18,28)21(32)11-24(17,5)26(13,35-15(3)30)22(33)12-34-14(2)29/h6-7,9,13,17-18,20-21,32H,8,10-12H2,1-5H3/t13-,17-,18-,20-,21-,23-,24-,25-,26-/m0/s1Y
- Key:BOBLHFUVNSFZPJ-JOYXJVLSSA-NY
N
Y (what is this?) (verify)Diflorasone diacetate is a topical steroid that comes in the form of a cream. It is manufactured by E. Fougera & Co. and is used as an anti-inflammatory and anti-itching agent, like other topical corticosteroids. It is prescribed for psoriasis[1] and atopic dermatitis, among other conditions. With respect to potency, it is regarded as a Class I corticosteroid [of classes I – VII] in the United States.[2]
No long-term animal studies have been done to determine whether diflorasone diacetate could have carcinogenic properties.[citation needed]
Little data is available regarding whether diflorasone diacetate would be present in great enough quantities to cause harm to an infant.[3]
References
- ^ Shupack JL, Jondreau L, Kenny C, Stiller MJ (1993). "Diflorasone diacetate ointment 0.05% versus betamethasone dipropionate ointment 0.05% in moderate-severe plaque-type psoriasis". Dermatology. 186 (2): 129–32. doi:10.1159/000247323. PMID 8428041.
- ^ "Topical Steroids Potency Chart". psoriasis.org.
- ^ "Diflorasone topical". Drugs.com.
External links
- "Diflorasone diacetate". Drug Information Portal. U.S. National Library of Medicine.
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- Antagonists: Aglepristone
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
- See also
- Glucocorticoid receptor modulators
- Mineralocorticoids and antimineralocorticoids
- List of corticosteroids
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