Methylprednisolone aceponate
Chemical compound
- D07AC14 (WHO)
- 86401-95-8
Y
- 63019
- DB14643 Y
- 56717
N
- ET54W9J4U2
- CHEBI:135762
- ChEMBL1697782
- DTXSID2023301
- Interactive image
- CCC(=O)O[C@@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2C[C@@H](C4=CC(=O)C=C[C@]34C)C)O)C)C(=O)COC(=O)C
InChI
- InChI=1S/C27H36O7/c1-6-23(32)34-27(22(31)14-33-16(3)28)10-8-19-18-11-15(2)20-12-17(29)7-9-25(20,4)24(18)21(30)13-26(19,27)5/h7,9,12,15,18-19,21,24,30H,6,8,10-11,13-14H2,1-5H3/t15-,18-,19-,21-,24+,25-,26-,27-/m0/s1N
- Key:DALKLAYLIPSCQL-YPYQNWSCSA-NN
N
Y (what is this?) (verify)Methylprednisolone aceponate, or methylprednisolone acetate propionate, sold under the brand names Advantan and Avancort, is a glucocorticoid and a corticosteroid ester—specifically the C17α propionate and C21 acetate diester of methylprednisolone.[1][2][3]
In Russia and some other countries the drug is available in 4 dosage forms differing in consistency and water content: emulsion (or lotion), cream, ointment and fatty ointment.[4]
See also
References
- ^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 811–. ISBN 978-1-4757-2085-3.
- ^ Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 675–. ISBN 978-3-88763-075-1.
- ^ Bieber T, Vick K, Fölster-Holst R, et al. (February 2007). "Efficacy and safety of methylprednisolone aceponate ointment 0.1% compared to tacrolimus 0.03% in children and adolescents with an acute flare of severe atopic dermatitis". Allergy. 62 (2): 184–9. doi:10.1111/j.1398-9995.2006.01269.x. PMID 17298428. S2CID 41761398.
- ^ "Advantan (methylprednisolone aceponate) Full Prescribing Information Lists". State Register of Medicines (in Russian). Retrieved 31 March 2023.
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| Natural | |
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| Synthetic |
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- Antagonists: Aglepristone
- Ketoconazole
- Mifepristone
- Ulipristal acetate
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
- See also
- Glucocorticoid receptor modulators
- Mineralocorticoids and antimineralocorticoids
- List of corticosteroids
 | This article about a steroid is a stub. You can help Wikipedia by expanding it. |
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