STK38

Protein-coding gene in the species Homo sapiens
STK38
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1PSB

Identifiers
AliasesSTK38, NDR, NDR1, serine/threonine kinase 38
External IDsOMIM: 606964; MGI: 2442572; HomoloGene: 56033; GeneCards: STK38; OMA:STK38 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for STK38
Genomic location for STK38
Band6p21.31Start36,493,892 bp[1]
End36,547,479 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for STK38
Genomic location for STK38
Band17|17 A3.3Start29,189,854 bp[2]
End29,226,969 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • palpebral conjunctiva

  • oocyte

  • secondary oocyte

  • granulocyte

  • nasal epithelium

  • amniotic fluid

  • epithelium of nasopharynx

  • mononuclear cell

  • monocyte

  • mucosa of paranasal sinus
Top expressed in
  • granulocyte

  • conjunctival fornix

  • thymus

  • blood

  • lacrimal gland

  • submandibular gland

  • spleen

  • body of femur

  • medullary collecting duct

  • ventricular zone
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • mitogen-activated protein kinase kinase kinase binding
  • transferase activity
  • nucleotide binding
  • protein kinase activity
  • protein serine/threonine kinase activity
  • protein binding
  • ATP binding
  • magnesium ion binding
  • metal ion binding
  • kinase activity
  • cadherin binding
Cellular component
  • cytoplasm
  • nucleus
  • cytosol
Biological process
  • protein phosphorylation
  • intracellular signal transduction
  • peptidyl-serine phosphorylation
  • negative regulation of MAP kinase activity
  • phosphorylation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

11329

106504

Ensembl

ENSG00000112079

ENSMUSG00000024006

UniProt

Q15208

Q91VJ4

RefSeq (mRNA)

NM_001305102
NM_007271

NM_134115
NM_001357173

RefSeq (protein)

NP_001292031
NP_009202

NP_598876
NP_001344102

Location (UCSC)Chr 6: 36.49 – 36.55 MbChr 17: 29.19 – 29.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein kinase 38 is an enzyme that in humans is encoded by the STK38 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112079 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024006 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Millward T, Cron P, Hemmings BA (Jun 1995). "Molecular cloning and characterization of a conserved nuclear serine(threonine) protein kinase". Proc Natl Acad Sci U S A. 92 (11): 5022–6. Bibcode:1995PNAS...92.5022M. doi:10.1073/pnas.92.11.5022. PMC 41840. PMID 7761441.
  6. ^ "Entrez Gene: STK38 serine/threonine kinase 38".

Further reading

  • Tripodis N, Mason R, Humphray SJ, et al. (1999). "Physical map of human 6p21.2-6p21.3: region flanking the centromeric end of the major histocompatibility complex". Genome Res. 8 (6): 631–43. doi:10.1101/gr.8.6.631. PMC 310739. PMID 9647638.
  • Millward TA, Heizmann CW, Schäfer BW, Hemmings BA (1998). "Calcium regulation of Ndr protein kinase mediated by S100 calcium-binding proteins". EMBO J. 17 (20): 5913–22. doi:10.1093/emboj/17.20.5913. PMC 1170919. PMID 9774336.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Tamaskovic R, Bichsel SJ, Rogniaux H, et al. (2003). "Mechanism of Ca2+-mediated regulation of NDR protein kinase through autophosphorylation and phosphorylation by an upstream kinase". J. Biol. Chem. 278 (9): 6710–8. doi:10.1074/jbc.M210590200. PMID 12493777.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
  • Bhattacharya S, Large E, Heizmann CW, et al. (2004). "Structure of the Ca2+/S100B/NDR kinase peptide complex: insights into S100 target specificity and activation of the kinase". Biochemistry. 42 (49): 14416–26. doi:10.1021/bi035089a. PMID 14661952.
  • Devroe E, Erdjument-Bromage H, Tempst P, Silver PA (2004). "Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases". J. Biol. Chem. 279 (23): 24444–51. doi:10.1074/jbc.M401999200. PMID 15067004.
  • Bichsel SJ, Tamaskovic R, Stegert MR, Hemmings BA (2005). "Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein". J. Biol. Chem. 279 (34): 35228–35. doi:10.1074/jbc.M404542200. PMID 15197186.
  • Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Devroe E, Silver PA, Engelman A (2005). "HIV-1 incorporates and proteolytically processes human NDR1 and NDR2 serine-threonine kinases". Virology. 331 (1): 181–9. doi:10.1016/j.virol.2004.10.023. PMID 15582665.
  • Amente S, Napolitano G, Licciardo P, et al. (2005). "Identification of proteins interacting with the RNAPII FCP1 phosphatase: FCP1 forms a complex with arginine methyltransferase PRMT5 and it is a substrate for PRMT5-mediated methylation". FEBS Lett. 579 (3): 683–9. doi:10.1016/j.febslet.2004.12.045. PMID 15670829. S2CID 33475235.
  • Hergovich A, Bichsel SJ, Hemmings BA (2005). "Human NDR kinases are rapidly activated by MOB proteins through recruitment to the plasma membrane and phosphorylation". Mol. Cell. Biol. 25 (18): 8259–72. doi:10.1128/MCB.25.18.8259-8272.2005. PMC 1234321. PMID 16135814.
  • Hergovich A, Lamla S, Nigg EA, Hemmings BA (2007). "Centrosome-associated NDR kinase regulates centrosome duplication". Mol. Cell. 25 (4): 625–34. doi:10.1016/j.molcel.2007.01.020. PMID 17317633.

External links

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Serine/threonine-protein kinase 38
  • v
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  • e
Non-specific serine/threonine protein kinases (EC 2.7.11.1)
Pyruvate dehydrogenase kinase (EC 2.7.11.2)
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)
Myosin-heavy-chain kinase (EC 2.7.11.7)
Fas-activated serine/threonine kinase (EC 2.7.11.8)
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)
  • -
IκB kinase (EC 2.7.11.10)
cAMP-dependent protein kinase (EC 2.7.11.11)
cGMP-dependent protein kinase (EC 2.7.11.12)
Protein kinase C (EC 2.7.11.13)
Rhodopsin kinase (EC 2.7.11.14)
Beta adrenergic receptor kinase (EC 2.7.11.15)
G-protein coupled receptor kinases (EC 2.7.11.16)
Ca2+/calmodulin-dependent (EC 2.7.11.17)
Myosin light-chain kinase (EC 2.7.11.18)
Phosphorylase kinase (EC 2.7.11.19)
Elongation factor 2 kinase (EC 2.7.11.20)
Polo kinase (EC 2.7.11.21)
Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
Polo kinase (EC 2.7.11.21)
Cyclin-dependent kinase (EC 2.7.11.22)
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)
Mitogen-activated protein kinase (EC 2.7.11.24)
MAP3K (EC 2.7.11.25)
Tau-protein kinase (EC 2.7.11.26)
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)
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Tropomyosin kinase (EC 2.7.11.28)
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Low-density-lipoprotein receptor kinase (EC 2.7.11.29)
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Receptor protein serine/threonine kinase (EC 2.7.11.30)
MAP2K
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