DAPK2

Protein-coding gene in the species Homo sapiens
DAPK2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1WMK, 1WRZ, 1Z9X, 1ZUZ, 1ZWS, 2A27, 2A2A, 2CKE

Identifiers
AliasesDAPK2, DRP-1, DRP1, death-associated protein kinase 2, death associated protein kinase 2
External IDsOMIM: 616567; MGI: 1341297; HomoloGene: 74940; GeneCards: DAPK2; OMA:DAPK2 - orthologs
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for DAPK2
Genomic location for DAPK2
Band15q22.31Start63,907,036 bp[1]
End64,072,033 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for DAPK2
Genomic location for DAPK2
Band9 C|9 35.75 cMStart66,158,223 bp[2]
End66,272,242 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right lobe of thyroid gland

  • left lobe of thyroid gland

  • right auricle

  • right lung

  • gastrocnemius muscle

  • muscle of thigh

  • upper lobe of left lung

  • left ventricle

  • blood

  • sural nerve
Top expressed in
  • muscle of thigh

  • membranous bone

  • body of femur

  • lumbar spinal ganglion

  • Dermatocranium

  • maxilla

  • lip

  • right lung

  • right lung lobe

  • tibiofemoral joint
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • nucleotide binding
  • protein kinase activity
  • calmodulin binding
  • kinase activity
  • protein serine/threonine kinase activity
  • protein binding
  • identical protein binding
  • ATP binding
Cellular component
  • cytoplasm
  • autophagosome lumen
  • cytoplasmic vesicle
  • Golgi apparatus
  • intracellular membrane-bounded organelle
  • nucleus
Biological process
  • regulation of apoptotic process
  • intracellular signal transduction
  • regulation of intrinsic apoptotic signaling pathway
  • phosphorylation
  • protein phosphorylation
  • positive regulation of eosinophil chemotaxis
  • regulation of autophagy
  • anoikis
  • positive regulation of neutrophil chemotaxis
  • protein autophosphorylation
  • neutrophil migration
  • apoptotic process
  • peptidyl-serine phosphorylation
  • peptidyl-threonine phosphorylation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23604

13143

Ensembl

ENSG00000035664

ENSMUSG00000032380

UniProt

Q9UIK4

Q8VDF3

RefSeq (mRNA)
NM_014326
NM_001363730
NM_001384997
NM_001384998
NM_001384999

NM_001385000

NM_010019

RefSeq (protein)

NP_055141
NP_001350659

NP_034149
NP_001391612

Location (UCSC)Chr 15: 63.91 – 64.07 MbChr 9: 66.16 – 66.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Death-associated protein kinase 2 is an enzyme that in humans is encoded by the DAPK2 gene.[5][6]

This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Gene overexpression induces cell apoptosis. It uses multiple polyadenylation sites.[6]

The DAPK2 mRNA may undergo alternative splicing to produce a DAPK3-like encoding transcript.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000035664 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032380 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kawai T, Nomura F, Hoshino K, Copeland NG, Gilbert DJ, Jenkins NA, Akira S (Jun 1999). "Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity". Oncogene. 18 (23): 3471–80. doi:10.1038/sj.onc.1202701. PMID 10376525. S2CID 19035227.
  6. ^ a b "Entrez Gene: DAPK2 death-associated protein kinase 2".
  7. ^ Shoval Y, Berissi H, Kimchi A, Pietrokovski S (2011). "New Modularity of DAP-Kinases: Alternative Splicing of the DRP-1 Gene Produces a ZIPk-Like Isoform". PLOS ONE. 6 (2): e17344. Bibcode:2011PLoSO...617344S. doi:10.1371/journal.pone.0017344. PMC 3050894. PMID 21408167.

Further reading

  • Inbal B, Shani G, Cohen O, et al. (2000). "Death-Associated Protein Kinase-Related Protein 1, a Novel Serine/Threonine Kinase Involved in Apoptosis". Mol. Cell. Biol. 20 (3): 1044–54. doi:10.1128/MCB.20.3.1044-1054.2000. PMC 85221. PMID 10629061.
  • Shani G, Henis-Korenblit S, Jona G, et al. (2001). "Autophosphorylation restrains the apoptotic activity of DRP-1 kinase by controlling dimerization and calmodulin binding". EMBO J. 20 (5): 1099–113. doi:10.1093/emboj/20.5.1099. PMC 145456. PMID 11230133.
  • Wong TS, Chang HW, Tang KC, et al. (2002). "High frequency of promoter hypermethylation of the death-associated protein-kinase gene in nasopharyngeal carcinoma and its detection in the peripheral blood of patients". Clin. Cancer Res. 8 (2): 433–7. PMID 11839660.
  • Chan MW, Chan LW, Tang NL, et al. (2002). "Hypermethylation of multiple genes in tumor tissues and voided urine in urinary bladder cancer patients". Clin. Cancer Res. 8 (2): 464–70. PMID 11839665.
  • Inbal B, Bialik S, Sabanay I, et al. (2002). "DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death". J. Cell Biol. 157 (3): 455–68. doi:10.1083/jcb.200109094. PMC 2173279. PMID 11980920.
  • Satoh A, Toyota M, Itoh F, et al. (2002). "DNA methylation and histone deacetylation associated with silencing DAP kinase gene expression in colorectal and gastric cancers". Br. J. Cancer. 86 (11): 1817–23. doi:10.1038/sj.bjc.6600319. PMC 2375414. PMID 12087472.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
  • Rizzi M, Tschan MP, Britschgi C, et al. (2007). "The death-associated protein kinase 2 is up-regulated during normal myeloid differentiation and enhances neutrophil maturation in myeloid leukemic cells". J. Leukoc. Biol. 81 (6): 1599–608. doi:10.1189/jlb.0606400. PMID 17347302.
  • v
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  • 1wmk: Human death-associated kinase DRP-1, mutant S308D d40
    1wmk: Human death-associated kinase DRP-1, mutant S308D d40
  • 1z9x: Human DRP-1 kinase, W305S S308A D40 mutant, crystal form with 3 monomers in the asymmetric unit
    1z9x: Human DRP-1 kinase, W305S S308A D40 mutant, crystal form with 3 monomers in the asymmetric unit
  • 1zws: Crystal structure of the catalytic domain of human DRP-1 kinase
    1zws: Crystal structure of the catalytic domain of human DRP-1 kinase
  • 2a27: Human DRP-1 kinase, W305S S308A D40 mutant, crystal form with 8 monomers in the asymmetric unit
    2a27: Human DRP-1 kinase, W305S S308A D40 mutant, crystal form with 8 monomers in the asymmetric unit
  • 2a2a: High-resolution crystallographic analysis of the autoinhibited conformation of a human death-associated protein kinase
    2a2a: High-resolution crystallographic analysis of the autoinhibited conformation of a human death-associated protein kinase
  • 2cke: HUMAN DEATH-ASSOCIATED DRP-1 KINASE IN COMPLEX WITH INHIBITOR
    2cke: HUMAN DEATH-ASSOCIATED DRP-1 KINASE IN COMPLEX WITH INHIBITOR
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Pyruvate dehydrogenase kinase (EC 2.7.11.2)
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)
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Fas-activated serine/threonine kinase (EC 2.7.11.8)
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)
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IκB kinase (EC 2.7.11.10)
cAMP-dependent protein kinase (EC 2.7.11.11)
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Beta adrenergic receptor kinase (EC 2.7.11.15)
G-protein coupled receptor kinases (EC 2.7.11.16)
Ca2+/calmodulin-dependent (EC 2.7.11.17)
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Phosphorylase kinase (EC 2.7.11.19)
Elongation factor 2 kinase (EC 2.7.11.20)
Polo kinase (EC 2.7.11.21)
Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
Polo kinase (EC 2.7.11.21)
Cyclin-dependent kinase (EC 2.7.11.22)
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)
Mitogen-activated protein kinase (EC 2.7.11.24)
MAP3K (EC 2.7.11.25)
Tau-protein kinase (EC 2.7.11.26)
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)
  • -
Tropomyosin kinase (EC 2.7.11.28)
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Low-density-lipoprotein receptor kinase (EC 2.7.11.29)
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Receptor protein serine/threonine kinase (EC 2.7.11.30)
MAP2K
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