CSPG5

Protein-coding gene in the species Homo sapiens
CSPG5
Identifiers
AliasesCSPG5, NGC, chondroitin sulfate proteoglycan 5
External IDsOMIM: 606775 MGI: 1352747 HomoloGene: 4795 GeneCards: CSPG5
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for CSPG5
Genomic location for CSPG5
Band3p21.31Start47,562,238 bp[1]
End47,580,792 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for CSPG5
Genomic location for CSPG5
Band9|9 F2Start110,072,851 bp[2]
End110,091,644 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • endothelial cell

  • retinal pigment epithelium

  • frontal pole

  • Brodmann area 23

  • Brodmann area 10

  • Region I of hippocampus proper

  • orbitofrontal cortex

  • entorhinal cortex

  • Brodmann area 46

  • superior frontal gyrus
Top expressed in
  • visual cortex

  • superior frontal gyrus

  • cingulate gyrus

  • prefrontal cortex

  • primary motor cortex

  • piriform cortex

  • olfactory tubercle

  • dorsomedial hypothalamic nucleus

  • globus pallidus

  • subiculum
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
  • growth factor activity
Cellular component
  • integral component of membrane
  • Golgi apparatus
  • endoplasmic reticulum membrane
  • membrane
  • Golgi membrane
  • plasma membrane
  • integral component of plasma membrane
  • extracellular region
  • cell surface
  • lysosomal lumen
  • endoplasmic reticulum
  • Golgi lumen
  • Golgi-associated vesicle membrane
  • glutamatergic synapse
  • GABA-ergic synapse
  • integral component of postsynaptic membrane
Biological process
  • cell differentiation
  • chondroitin sulfate biosynthetic process
  • modulation of chemical synaptic transmission
  • intracellular transport
  • nervous system development
  • multicellular organism development
  • chondroitin sulfate catabolic process
  • regulation of growth
  • dermatan sulfate biosynthetic process
  • regulation of signaling receptor activity
  • trans-synaptic signaling, modulating synaptic transmission
  • regulation of synaptic vesicle exocytosis
  • cytoskeleton organization
  • glial cell projection elongation
  • positive regulation of substrate adhesion-dependent cell spreading
  • signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10675

29873

Ensembl

ENSG00000114646

ENSMUSG00000032482

UniProt

O95196

Q71M36

RefSeq (mRNA)

NM_006574
NM_001206942
NM_001206943
NM_001206944
NM_001206945

NM_001166273
NM_013884

RefSeq (protein)

NP_001193871
NP_001193872
NP_001193873
NP_001193874
NP_006565

NP_001159745
NP_038912

Location (UCSC)Chr 3: 47.56 – 47.58 MbChr 9: 110.07 – 110.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Chondroitin sulfate proteoglycan 5 is a protein that in humans is encoded by the CSPG5 gene.[5][6]

Interactions

CSPG5 has been shown to interact with GOPC.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000114646 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032482 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Yasuda Y, Tokita Y, Aono S, Matsui F, Ono T, Sonta S, Watanabe E, Nakanishi Y, Oohira A (May 1999). "Cloning and chromosomal mapping of the human gene of neuroglycan C (NGC), a neural transmembrane chondroitin sulfate proteoglycan with an EGF module". Neurosci Res. 32 (4): 313–22. doi:10.1016/S0168-0102(98)00098-4. PMID 9950058. S2CID 39609929.
  6. ^ "Entrez Gene: CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C)".
  7. ^ Hassel, Burkhard; Schreff Matthias; Stube Eva-Maria; Blaich Uta; Schumacher Stefan (Oct 2003). "CALEB/NGC interacts with the Golgi-associated protein PIST". J. Biol. Chem. 278 (41). United States: 40136–43. doi:10.1074/jbc.M305577200. ISSN 0021-9258. PMID 12885772.

Further reading

  • Ichihara-Tanaka K, Oohira A, Rumsby M, Muramatsu T (2006). "Neuroglycan C is a novel midkine receptor involved in process elongation of oligodendroglial precursor-like cells". J. Biol. Chem. 281 (41): 30857–64. doi:10.1074/jbc.M602228200. PMID 16901907.
  • Aono S, Tokita Y, Yasuda Y, et al. (2006). "Expression and identification of a new splice variant of neuroglycan C, a transmembrane chondroitin sulfate proteoglycan, in the human brain". J. Neurosci. Res. 83 (1): 110–8. doi:10.1002/jnr.20698. PMID 16299773. S2CID 45306074.
  • Kinugasa Y, Ishiguro H, Tokita Y, et al. (2004). "Neuroglycan C, a novel member of the neuregulin family". Biochem. Biophys. Res. Commun. 321 (4): 1045–9. doi:10.1016/j.bbrc.2004.07.066. PMID 15358134.
  • Hassel B, Schreff M, Stube EM, et al. (2003). "CALEB/NGC interacts with the Golgi-associated protein PIST". J. Biol. Chem. 278 (41): 40136–43. doi:10.1074/jbc.M305577200. PMID 12885772.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.

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