Zoxazolamine
Withdrawn muscle relaxant drug
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| Other names | McN-485 |
| Routes of administration | Oral |
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| Formula | C7H5ClN2O |
| Molar mass | 168.58 g·mol−1 |
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Zoxazolamine (INN, USAN, BAN) (brand name Contrazole, Deflexol, Flexin, Miazol, Uri-Boi, Zoxamine, Zoxine) is a muscle relaxant that is no longer marketed.[1][2] It was synthesized in 1953 and introduced clinically in 1955 but was withdrawn due to hepatotoxicity.[1][2][3] One of its active metabolites, chlorzoxazone, was found to show less toxicity, and was subsequently marketed in place of zoxazolamine.[3] These drugs activate IKCa channels.[4]
References
- ^ a b Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 48–. ISBN 978-1-4757-2085-3.
- ^ a b Kar A (1 January 2005). Medicinal Chemistry. New Age International. pp. 185–. ISBN 978-81-224-1565-0.
- ^ a b Lowry W (6 December 2012). Forensic Toxicology: Controlled Substances and Dangerous Drugs. Springer Science & Business Media. pp. 166–. ISBN 978-1-4684-3444-6.
- ^ Offermanns S (14 August 2008). Encyclopedia of Molecular Pharmacology. Springer Science & Business Media. pp. 996–. ISBN 978-3-540-38916-3.
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Skeletal muscle relaxants (M03)
(primarily antinicotinic,
NMJ block)
| Non-depolarizing |
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| Depolarizing |
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| ACh release inhibitors |
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