Dimethyltubocurarinium chloride

Chemical compound
  • M03AA04 (WHO)
Identifiers
  • (1S,16R)-9,10,21,25-Tetramethoxy-15,15,30,30-tetramethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.23,6.18,12.118,22.027,31.016,34]hexatriaconta-3,5,8(34),9,11,18(33),19,21,24,26,31,35-dodecaene-15,30-diium dichloride
CAS Number
  • 33335-58-9 checkY
PubChem CID
  • 71931
DrugBank
  • DB00416 ☒N
ChemSpider
  • 64941
UNII
  • 15BE4G33H2
CompTox Dashboard (EPA)
  • DTXSID10954969 Edit this at Wikidata
ECHA InfoCard100.046.768 Edit this at WikidataChemical and physical dataFormulaC40H48Cl2N2O6Molar mass723.73 g·mol−13D model (JSmol)
  • C[N+]1(CCc2cc(c3cc2[C@@H]1Cc4ccc(cc4)Oc5c6c(cc(c5OC)OC)CC[N+]([C@@H]6Cc7ccc(c(c7)O3)OC)(C)C)OC)C.[Cl-].[Cl-]
InChI
  • InChI=1S/C40H48N2O6.2ClH/c1-41(2)17-15-27-22-34(44-6)36-24-30(27)31(41)19-25-9-12-29(13-10-25)47-40-38-28(23-37(45-7)39(40)46-8)16-18-42(3,4)32(38)20-26-11-14-33(43-5)35(21-26)48-36;;/h9-14,21-24,31-32H,15-20H2,1-8H3;2*1H/q+2;;/p-2/t31-,32+;;/m0../s1
  • Key:IRPSJVWFSWAZSZ-OIUSMDOTSA-L
 ☒NcheckY (what is this?)  (verify)

Dimethyltubocurarinium chloride (INN; also known as metocurine chloride (USAN) and dimethyltubocurarine chloride) is a non-depolarizing nicotinic acetylcholine receptor antagonist used as a muscle relaxant.[1]

References

  1. ^ Service, United States Public Health (1965). Public Health Service Publication. U.S. Department of Health, Education, and Welfare, Public Health Service, Environmental Health Service, National Air Pollution Control Administration. p. 126.
  • v
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Skeletal muscle relaxants (M03)
Peripherally acting
(primarily antinicotinic,
NMJ block)
Non-depolarizing
Curare alkaloids
4° ammonium agents
Depolarizing
ACh release inhibitors
Centrally acting
Carbamic acid esters
Benzodiazepines
Nonbenzodiazepines
Thienodiazepines
Quinazolines
Anticholinergics
(Antimuscarinics)
Other
Directly acting
  • v
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  • e
nAChRsTooltip Nicotinic acetylcholine receptors
Agonists
(and PAMsTooltip positive allosteric modulators)
Antagonists
(and NAMsTooltip negative allosteric modulators)
Precursors
(and prodrugs)
See also
Receptor/signaling modulators
Muscarinic acetylcholine receptor modulators
Acetylcholine metabolism/transport modulators
Stub icon

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