ZMIZ1

Protein-coding gene in the species Homo sapiens
ZMIZ1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

5AIZ

Identifiers
AliasesZMIZ1, MIZ, RAI17, TRAFIP10, ZIMP10, hZIMP10, zinc finger MIZ-type containing 1, NEDDFSA
External IDsOMIM: 607159; MGI: 3040693; HomoloGene: 10667; GeneCards: ZMIZ1; OMA:ZMIZ1 - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for ZMIZ1
Genomic location for ZMIZ1
Band10q22.3Start79,068,966 bp[1]
End79,316,519 bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for ZMIZ1
Genomic location for ZMIZ1
Band14|14 A3Start25,459,609 bp[2]
End25,667,167 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tibia

  • seminal vesicula

  • inferior olivary nucleus

  • ganglionic eminence

  • endothelial cell

  • synovial joint

  • urethra

  • vulva

  • hair follicle

  • caput epididymis
Top expressed in
  • epithelium of stomach

  • molar

  • cumulus cell

  • olfactory epithelium

  • renal corpuscle

  • vas deferens

  • cerebellar vermis

  • submandibular gland

  • ganglionic eminence

  • endocardial cushion
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • zinc ion binding
  • metal ion binding
Cellular component
  • cytoplasm
  • nucleus
  • nuclear speck
  • intracellular membrane-bounded organelle
  • nucleoplasm
Biological process
  • vasculogenesis
  • heart morphogenesis
  • developmental growth
  • in utero embryonic development
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • vitellogenesis
  • artery morphogenesis
  • positive regulation of fibroblast proliferation
  • positive regulation of T cell differentiation
  • positive regulation of Notch signaling pathway
  • positive regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

57178

328365

Ensembl

ENSG00000108175

ENSMUSG00000007817

UniProt

Q9ULJ6

Q6P1E1

RefSeq (mRNA)

NM_020338

NM_001033402
NM_183208
NM_001310666

RefSeq (protein)

NP_065071

NP_001297595
NP_899031

Location (UCSC)Chr 10: 79.07 – 79.32 MbChr 14: 25.46 – 25.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger MIZ domain-containing protein 1 is a protein that in humans is encoded by the ZMIZ1 gene.[5]

Interactions

ZMIZ1 has been shown to interact with Androgen receptor.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000108175 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000007817 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: ZMIZ1 zinc finger, MIZ-type containing 1".
  6. ^ Sharma M, Li X, Wang Y, Zarnegar M, Huang CY, Palvimo JJ, Lim B, Sun Z (Nov 2003). "hZimp10 is an androgen receptor co-activator and forms a complex with SUMO-1 at replication foci". EMBO J. 22 (22): 6101–6114. doi:10.1093/emboj/cdg585. PMC 275443. PMID 14609956.

Further reading

  • Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–113. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–358. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–345. doi:10.1093/dnares/6.5.337. PMID 10574462.
  • Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–3496. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
  • Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–1784. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
  • Sharma M, Li X, Wang Y, Zarnegar M, Huang CY, Palvimo JJ, Lim B, Sun Z (2004). "hZimp10 is an androgen receptor co-activator and forms a complex with SUMO-1 at replication foci". EMBO J. 22 (22): 6101–6114. doi:10.1093/emboj/cdg585. PMC 275443. PMID 14609956.
  • Li X, Thyssen G, Beliakoff J, Sun Z (2006). "The novel PIAS-like protein hZimp10 enhances Smad transcriptional activity". J. Biol. Chem. 281 (33): 23748–23756. doi:10.1074/jbc.M508365200. PMID 16777850.
  • Cappuzzello C, Melchionna R, Mangoni A, Tripodi G, Ferrari P, Torielli L, Arcelli D, Helmer-Citterich M, Bianchi G, Capogrossi MC, Napolitano M (2007). "Role of rat alpha adducin in angiogenesis: null effect of the F316Y polymorphism". Cardiovasc. Res. 75 (3): 608–617. doi:10.1016/j.cardiores.2007.04.020. PMID 17512505.
  • Lee J, Beliakoff J, Sun Z (2007). "The novel PIAS-like protein hZimp10 is a transcriptional co-activator of the p53 tumor suppressor". Nucleic Acids Res. 35 (13): 4523–4534. doi:10.1093/nar/gkm476. PMC 1935018. PMID 17584785.

External links

  • Overview of all the structural information available in the PDB for UniProt: Q9ULJ6 (Zinc finger MIZ domain-containing protein 1) at the PDBe-KB.
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