Varlilumab
Anti-CD27 antibody and helps activate T-cells
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Varlilumab (INN;[1] development code CDX-1127) is a monoclonal antibody designed for immunotherapy for solid tumors and hematologic malignancies.[2] It is an anti-CD27 antibody and helps activate T-cells.[3]
This drug was developed by Celldex Therapeutics.
It (in combination with ONT-10) has undergone a phase 1B clinical trial for advanced breast or ovarian cancer.[4] In combination with anti-PD-1 nivolumab it has undergone a phase 1/2 trial for advanced refractory solid tumours[5]
References
- ^ World Health Organization (2014). "International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 111" (PDF). WHO Drug Information. 28 (2).
- ^ Statement On A Nonproprietary Name Adopted By The USAN Council - Varlilumab, American Medical Association.
- ^ Melão A (June 2017). "Varlilumab-Opdivo Combo Stabilizes or Shrinks Tumors in 80% of Solid-cancer Patients, Trial Shows".
- ^ Clinical trial number NCT02270372 for "Study of ONT-10 and Varlilumab to Treat Advanced Ovarian or Breast Cancer" at ClinicalTrials.gov
- ^ Clinical trial number NCT02335918 for "A Dose Escalation and Cohort Expansion Study of Anti-CD27 (Varlilumab) and Anti-PD-1 (Nivolumab) in Advanced Refractory Solid Tumors" at ClinicalTrials.gov
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