UGT2B17

Protein-coding gene in the species Homo sapiens
UGT2B17
Identifiers
AliasesUGT2B17, BMND12, UDPGT2B17, UDP glucuronosyltransferase family 2 member B17
External IDsOMIM: 601903; MGI: 1919023; HomoloGene: 68144; GeneCards: UGT2B17; OMA:UGT2B17 - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for UGT2B17
Genomic location for UGT2B17
Band4q13.2Start68,537,173 bp[1]
End68,576,413 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for UGT2B17
Genomic location for UGT2B17
Band5|5 E1Start87,064,497 bp[2]
End87,074,389 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of transverse colon

  • mucosa of ileum

  • mucosa of sigmoid colon

  • duodenum

  • appendix

  • epithelium of colon

  • jejunal mucosa

  • rectum

  • right lobe of liver

  • pancreatic epithelial cell
Top expressed in
  • left lobe of liver

  • embryo

  • lumbar subsegment of spinal cord

  • right ventricle

  • tibiofemoral joint

  • sexually immature organism

  • medial head of gastrocnemius muscle

  • lumbar spinal ganglion

  • stria vascularis

  • carotid body
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • glycosyltransferase activity
  • transferase activity
  • glucuronosyltransferase activity
  • retinoic acid binding
  • hexosyltransferase activity
  • UDP-glycosyltransferase activity
Cellular component
  • integral component of membrane
  • organelle membrane
  • endoplasmic reticulum membrane
  • membrane
  • intracellular membrane-bounded organelle
  • endoplasmic reticulum
Biological process
  • steroid metabolic process
  • metabolism
  • cellular glucuronidation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7367

71773

Ensembl

ENSG00000197888

ENSMUSG00000035836

UniProt

O75795

Q8R084

RefSeq (mRNA)

NM_001077

NM_152811

RefSeq (protein)

NP_001068

NP_690024

Location (UCSC)Chr 4: 68.54 – 68.58 MbChr 5: 87.06 – 87.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

UDP-glucuronosyltransferase 2B17 is an enzyme that in humans is encoded by the UGT2B17 gene.[5][6]

UGT2B17 belongs to the family of UDP-glucuronosyltransferases (UGTs; EC 2.4.1.17), enzymes that catalyze the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a variety of substrates, including steroid hormones.[supplied by OMIM][6] It also metabolizes 3-hydroxycotinine, which is minor nicotine metabolite[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000197888 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035836 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Beaulieu M, Levesque E, Hum DW, Belanger A (Nov 1996). "Isolation and characterization of a novel cDNA encoding a human UDP-glucuronosyltransferase active on C19 steroids". J Biol Chem. 271 (37): 22855–62. doi:10.1074/jbc.271.37.22855. PMID 8798464.
  6. ^ a b "Entrez Gene: UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17".
  7. ^ Chen G, Giambrone NE, Dluzen DF, Muscat JE, Berg A, Gallagher CJ, Lazarus P (October 2010). "Glucuronidation genotypes and nicotine metabolic phenotypes: importance of functional UGT2B10 and UGT2B17 polymorphisms". Cancer Research. 70 (19): 7543–52. doi:10.1158/0008-5472.CAN-09-4582. PMC 2998997. PMID 20876810.

Further reading

  • Chung LW, Coffey DS (1978). "Androgen glucuronide. II. Differences in its formation by human normal and benign hyperplastic prostates". Investigative Urology. 15 (5): 385–8. PMID 76619.
  • Moghissi E, Ablan F, Horton R (1984). "Origin of plasma androstanediol glucuronide in men". J. Clin. Endocrinol. Metab. 59 (3): 417–21. doi:10.1210/jcem-59-3-417. PMID 6746859.
  • Beaulieu M, Lévesque E, Tchernof A, et al. (1997). "Chromosomal localization, structure, and regulation of the UGT2B17 gene, encoding a C19 steroid metabolizing enzyme". DNA Cell Biol. 16 (10): 1143–54. doi:10.1089/dna.1997.16.1143. PMID 9364925.
  • Collier AC, Ganley NA, Tingle MD, et al. (2002). "UDP-glucuronosyltransferase activity, expression and cellular localization in human placenta at term". Biochem. Pharmacol. 63 (3): 409–19. doi:10.1016/S0006-2952(01)00890-5. PMID 11853692.
  • Chouinard S, Pelletier G, Bélanger A, Barbier O (2005). "Cellular specific expression of the androgen-conjugating enzymes UGT2B15 and UGT2B17 in the human prostate epithelium". Endocr. Res. 30 (4): 717–25. doi:10.1081/ERC-200044014. PMID 15666817. S2CID 10971899.
  • Lazarus P, Zheng Y, Aaron Runkle E, et al. (2006). "Genotype-phenotype correlation between the polymorphic UGT2B17 gene deletion and NNAL glucuronidation activities in human liver microsomes". Pharmacogenet. Genomics. 15 (11): 769–78. doi:10.1097/01.fpc.0000175596.52443.ef. PMID 16220109. S2CID 10171438.
  • Jakobsson J, Ekström L, Inotsume N, et al. (2006). "Large differences in testosterone excretion in Korean and Swedish men are strongly associated with a UDP-glucuronosyl transferase 2B17 polymorphism". J. Clin. Endocrinol. Metab. 91 (2): 687–93. doi:10.1210/jc.2005-1643. PMID 16332934.
  • Park J, Chen L, Ratnashinge L, et al. (2006). "Deletion polymorphism of UDP-glucuronosyltransferase 2B17 and risk of prostate cancer in African American and Caucasian men". Cancer Epidemiol. Biomarkers Prev. 15 (8): 1473–8. doi:10.1158/1055-9965.EPI-06-0141. PMID 16896035.
  • Gallagher CJ, Muscat JE, Hicks AN, et al. (2007). "The UDP-glucuronosyltransferase 2B17 gene deletion polymorphism: sex-specific association with urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronidation phenotype and risk for lung cancer". Cancer Epidemiol. Biomarkers Prev. 16 (4): 823–8. doi:10.1158/1055-9965.EPI-06-0823. PMID 17416778.
  • Park JY, Tanner JP, Sellers TA, et al. (2007). "Association between polymorphisms in HSD3B1 and UGT2B17 and prostate cancer risk". Urology. 70 (2): 374–9. doi:10.1016/j.urology.2007.03.001. PMID 17826523.
  • Chouinard S, Barbier O, Bélanger A (2008). "UDP-glucuronosyltransferase 2B15 (UGT2B15) and UGT2B17 enzymes are major determinants of the androgen response in prostate cancer LNCaP cells". J. Biol. Chem. 282 (46): 33466–74. doi:10.1074/jbc.M703370200. PMID 17848572.
  • v
  • t
  • e
2.4.1: Hexosyl-
transferases
Glucosyl-
Galactosyl-
Glucuronosyl-
Fucosyl-
Mannosyl-
2.4.2: Pentosyl-
transferases
Ribose
ADP-ribosyltransferase
Phosphoribosyltransferase
Other
Other
2.4.99: Sialyl
transferases


Stub icon

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e