Tetradecylthioacetic acid

Tetradecylthioacetic acid

Names
Preferred IUPAC name (Tetradecylsulfanyl)acetic acid
Other names 1-(Carboxymethylthio)tetradecane
Identifiers
CAS Number	2921-20-2 Y
3D model (JSmol)	Interactive image
Abbreviations	TTA; CMTD
ChemSpider	102869
PubChem CID	114924
UNII	7ZU5I25S2O Y
CompTox Dashboard (EPA)	DTXSID0040759
InChI InChI=1S/C16H32O2S/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-19-15-16(17)18/h2-15H2,1H3,(H,17,18) Key: IPBCWPPBAWQYOO-UHFFFAOYSA-N InChI=1/C16H32O2S/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-19-15-16(17)18/h2-15H2,1H3,(H,17,18) Key: IPBCWPPBAWQYOO-UHFFFAOYAU
SMILES O=C(O)CSCCCCCCCCCCCCCC
Properties
Chemical formula	C16H32O2S
Molar mass	288.49 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Tetradecylthioacetic acid (TTA) is a synthetic fatty acid used as a nutritional supplement.

TTA acts as a peroxisome proliferator-activated receptor alpha (PPARα) agonist and increases mitochondrial fatty acid oxidation in vitro.^[1] In rodent studies, TTA has been reported to have other activities such as reducing inflammation^[2] and preventing high fat diet induced adiposity and insulin resistance.^[3]

In human clinical study, there have been mixed observations in preliminary studies. One Phase I study showed no significant changes in the blood lipids or free fatty acids^[4] and another showed that TTA attenuates dyslipidemia in patients with type 2 diabetes mellitus.^[1]

References