TUBGCP5

Protein-coding gene in the species Homo sapiens
TUBGCP5
Identifiers
AliasesTUBGCP5, GCP5, tubulin gamma complex associated protein 5
External IDsOMIM: 608147; MGI: 2178836; HomoloGene: 14172; GeneCards: TUBGCP5; OMA:TUBGCP5 - orthologs
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for TUBGCP5
Genomic location for TUBGCP5
Band15q11.2Start22,983,192 bp[1]
End23,039,572 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for TUBGCP5
Genomic location for TUBGCP5
Band7|7 B5Start55,443,902 bp[2]
End55,481,425 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sural nerve

  • Achilles tendon

  • testicle

  • corpus callosum

  • gonad

  • endometrium

  • body of pancreas

  • tonsil

  • canal of the cervix

  • smooth muscle tissue
Top expressed in
  • spermatocyte

  • ascending aorta

  • aortic valve

  • tail of embryo

  • genital tubercle

  • neural layer of retina

  • superior cervical ganglion

  • Rostral migratory stream

  • ventricular zone

  • facial motor nucleus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • microtubule binding
  • structural constituent of cytoskeleton
  • microtubule minus-end binding
  • gamma-tubulin binding
Cellular component
  • centrosome
  • spindle pole
  • equatorial microtubule organizing center
  • microtubule organizing center
  • spindle pole body
  • microtubule
  • cytoskeleton
  • cytoplasm
  • cytosol
  • gamma-tubulin complex
Biological process
  • centrosome duplication
  • microtubule nucleation by interphase microtubule organizing center
  • mitotic spindle assembly
  • cytoplasmic microtubule organization
  • microtubule cytoskeleton organization
  • microtubule nucleation
  • meiosis
  • mitotic cell cycle
  • spindle assembly
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

114791

233276

Ensembl

ENSG00000276856
ENSG00000275835
ENSG00000280807

ENSMUSG00000033790

UniProt

Q96RT8

Q8BKN5

RefSeq (mRNA)
NM_001102610
NM_052903
NM_001354372
NM_001354373
NM_001354374

NM_001354375
NM_001354376
NM_001354377
NM_001354378

NM_146190
NM_001360873
NM_001360874

RefSeq (protein)
NP_001096080
NP_443135
NP_001341301
NP_001341302
NP_001341303

NP_001341304
NP_001341305
NP_001341306
NP_001341307

NP_666302
NP_001347802
NP_001347803

Location (UCSC)Chr 15: 22.98 – 23.04 MbChr 7: 55.44 – 55.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Gamma-tubulin complex component 5 is a protein that in humans is encoded by the TUBGCP5 gene.[5][6] It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.

See also

References

  1. ^ a b c ENSG00000275835, ENSG00000280807 GRCh38: Ensembl release 89: ENSG00000276856, ENSG00000275835, ENSG00000280807 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033790 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Murphy SM, Preble AM, Patel UK, O'Connell KL, Dias DP, Moritz M, Agard D, Stults JT, Stearns T (Nov 2001). "GCP5 and GCP6: two new members of the human gamma-tubulin complex" (PDF). Mol Biol Cell. 12 (11): 3340–52. doi:10.1091/mbc.12.11.3340. PMC 60259. PMID 11694571.
  6. ^ "Entrez Gene: TUBGCP5 tubulin, gamma complex associated protein 5".

Further reading

  • Bittel DC, Kibiryeva N, Butler MG (2006). "Expression of 4 genes between chromosome 15 breakpoints 1 and 2 and behavioral outcomes in Prader–Willi syndrome". Pediatrics. 118 (4): e1276–83. doi:10.1542/peds.2006-0424. PMC 5453799. PMID 16982806.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Chai JH, Locke DP, Greally JM, et al. (2003). "Identification of four highly conserved genes between breakpoint hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes deletion region that have undergone evolutionary transposition mediated by flanking duplicons". Am. J. Hum. Genet. 73 (4): 898–925. doi:10.1086/378816. PMC 1180611. PMID 14508708.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins". DNA Res. 8 (4): 179–87. doi:10.1093/dnares/8.4.179. PMID 11572484.


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