Sodium ferric gluconate complex

US DailyMed: Ferrlecit

Routes of
administrationIntravenous (IV)ATC code

B03AC (WHO)

Legal statusLegal status

US: ℞-only

IdentifiersCAS Number

34089-81-1^Y

PubChem CID

76968835

DrugBank

DB09517

ChemSpider

34989638

UNII

CC9149U2QX

KEGG

D05859

CompTox Dashboard (EPA)

DTXSID80187686

Chemical and physical dataFormulaC₆₆H₁₂₁Fe₂NaO₆₅Molar mass2089.309 g·mol⁻¹3D model (JSmol)

Interactive image

SMILES

O[C@H]([C@@H](O)C(O[Na])=O)[C@H](O)[C@H](O)CO.O[C@H]([C@@H](O)C(O1)=O)[C@H](O)[C@H](O)CO.[Fe]1(OC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)OC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

InChI

InChI=1S/5C12H22O11.C6H12O7.2Fe.Na.3O/c5*13-1-4-6(16)8(18)9(19)11(21-4)23-12(3-15)10(20)7(17)5(2-14)22-12;7-1-2(8)3(9)4(10)5(11)6(12)13;;;;;;/h5*4-11,13-20H,1-3H2;2-5,7-11H,1H2,(H,12,13);;;;;;/q;;;;;;2*+3;+1;3*-2/p-1/t5*4-,5-,6-,7-,8+,9-,10+,11-,12+;2-,3-,4+,5-;;;;;;/m111111....../s1
Key:MQBDAEHWGRMADS-XNHLMZCASA-M

Sodium ferric gluconate complex, sold under the brand name Ferrlecit, is an intravenously administered iron medication for the treatment of iron deficiency anemia in adults and in children aged six years and older with chronic kidney disease receiving hemodialysis who are receiving supplemental epoetin therapy.^[2] The macromolecule has an apparent molecular weight of 289,000–440,000 Dalton.^[3]^[4]

The most common side effects in adults are nausea, vomiting and/or diarrhea, injection site reaction, hypotension, cramps, hypertension, dizziness, dyspnea, chest pain, leg cramps, and pain.^[2] In children the most common side effects are hypotension, headache, hypertension, tachycardia and vomiting.^[2]

References

^ "Sodium ferric gluconate complex Use During Pregnancy". Drugs.com. 16 December 2019. Retrieved 2 April 2020.
^ ^a ^b ^c "Ferrlecit- sodium ferric gluconate complex injection". DailyMed. 25 September 2019. Retrieved 2 April 2020.
^ "Sodium ferric gluconate complex". www.drugbank.ca. Retrieved 21 June 2020.^{[title missing]}
^ Fishbane S, Wagner J (May 2001). "Sodium ferric gluconate complex in the treatment of iron deficiency for patients on dialysis". American Journal of Kidney Diseases. 37 (5): 879–83. doi:10.1016/s0272-6386(05)80001-0. PMID 11325667.