SUN domain-containing protein 5

Protein-coding gene in the species Homo sapiens
SUN5
Identifiers
AliasesSUN5, SPAG4L, TSARG4, dJ726C3.1, Sad1 and UNC84 domain containing 5, SPGF16
External IDsOMIM: 613942; MGI: 1923657; HomoloGene: 12640; GeneCards: SUN5; OMA:SUN5 - orthologs
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for SUN5
Genomic location for SUN5
Band20q11.21Start32,983,773 bp[1]
End33,004,433 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for SUN5
Genomic location for SUN5
Band2|2 H1Start153,698,108 bp[2]
End153,713,004 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • sperm

  • endothelial cell

  • external globus pallidus

  • synovial joint

  • jejunal mucosa

  • right coronary artery

  • muscular system

  • muscle

  • connective tissue
Top expressed in
  • spermatid

  • seminiferous tubule

  • spermatocyte

  • temporal muscle

  • ear

  • islet of Langerhans

  • carotid body
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein-membrane adaptor activity
  • molecular function
Cellular component
  • integral component of membrane
  • membrane
  • nucleus
  • nuclear inner membrane
  • sperm connecting piece
  • Golgi apparatus
  • nuclear envelope
  • meiotic nuclear membrane microtubule tethering complex
Biological process
  • nuclear envelope organization
  • spermatogenesis
  • cell differentiation
  • spermatid development
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

140732

76407

Ensembl

ENSG00000167098

ENSMUSG00000027480

UniProt

Q8TC36

Q9DA32

RefSeq (mRNA)

NM_080675

NM_029599
NM_001305048

RefSeq (protein)

NP_542406

NP_001291977
NP_083875

Location (UCSC)Chr 20: 32.98 – 33 MbChr 2: 153.7 – 153.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

SUN domain-containing protein 5, formerly known as sperm-associated antigen 4-like protein (SPAGL4), is a protein that in humans is encoded by the SUN5 gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167098 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027480 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tarnasky H, Gill D, Murthy S, Shao X, Demetrick DJ, van der Hoorn FA (Oct 1998). "A novel testis-specific gene, SPAG4, whose product interacts specifically with outer dense fiber protein ODF27, maps to human chromosome 20q11.2". Cytogenet Cell Genet. 81 (1): 65–7. doi:10.1159/000014990. hdl:1807.1/829. PMID 9691178. S2CID 30497041.
  6. ^ Shao X, Tarnasky HA, Lee JP, Oko R, van der Hoorn FA (Jul 1999). "Spag4, a novel sperm protein, binds outer dense-fiber protein Odf1 and localizes to microtubules of manchette and axoneme". Dev Biol. 211 (1): 109–23. doi:10.1006/dbio.1999.9297. PMID 10373309.
  7. ^ "Entrez Gene: SPAG4L sperm associated antigen 4-like".

Further reading

  • Kierszenbaum AL, Tres LL (2003). "Bypassing natural sperm selection during fertilization: the azh mutant offspring experience and the alternative of spermiogenesis in vitro". Mol. Cell. Endocrinol. 187 (1–2): 133–8. doi:10.1016/S0303-7207(01)00692-X. PMID 11988320. S2CID 27072243.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Xing XW, Li LY, Fu JJ, et al. (2003). "[Cloning of cDNA of TSARG4, a human spermatogenesis related gene]". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao. 35 (3): 283–8. PMID 12621555.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.


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