SRXN1

Protein-coding gene in the species Homo sapiens
SRXN1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1XW4, 1YZS, 2B6F, 2RII, 3CYI, 3HY2

Identifiers
AliasesSRXN1, C20orf139, Npn3, SRX, SRX1, sulfiredoxin 1
External IDsOMIM: 617583; MGI: 104971; HomoloGene: 32722; GeneCards: SRXN1; OMA:SRXN1 - orthologs
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for SRXN1
Genomic location for SRXN1
Band20p13Start646,615 bp[1]
End653,200 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for SRXN1
Genomic location for SRXN1
Band2|2 G3Start151,947,436 bp[2]
End151,953,296 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • islet of Langerhans

  • left adrenal gland

  • stromal cell of endometrium

  • left ventricle

  • gastrocnemius muscle

  • monocyte

  • body of stomach

  • dorsolateral prefrontal cortex

  • left lobe of thyroid gland

  • anterior pituitary
Top expressed in
  • adrenal gland

  • ileum

  • jejunum

  • duodenum

  • pituitary gland

  • pontine nuclei

  • blood

  • lateral geniculate nucleus

  • ankle joint

  • adrenal medulla
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • nucleotide binding
  • oxidoreductase activity
  • antioxidant activity
  • ATP binding
  • oxidoreductase activity, acting on a sulfur group of donors
  • sulfiredoxin activity
  • protein binding
Cellular component
  • cytoplasm
  • cytosol
Biological process
  • cellular oxidant detoxification
  • response to oxidative stress
  • cellular response to oxidative stress
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

140809

76650

Ensembl

ENSG00000271303

ENSMUSG00000032802

UniProt

Q9BYN0

Q9D975

RefSeq (mRNA)

NM_080725

NM_029688

RefSeq (protein)

NP_542763

NP_083964

Location (UCSC)Chr 20: 0.65 – 0.65 MbChr 2: 151.95 – 151.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sulfiredoxin-1 is a protein that in humans is encoded by the SRXN1 gene.[5]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000271303 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032802 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: SRXN1 sulfiredoxin 1 homolog (S. Cerevisiae)".

Further reading

  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–51. Bibcode:2001Sci...291.1304V. doi:10.1126/science.1058040. PMID 11181995.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Chang TS, Jeong W, Woo HA, et al. (2005). "Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine". J. Biol. Chem. 279 (49): 50994–1001. doi:10.1074/jbc.M409482200. PMID 15448164.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Woo HA, Jeong W, Chang TS, et al. (2005). "Reduction of cysteine sulfinic acid by sulfiredoxin is specific to 2-cys peroxiredoxins". J. Biol. Chem. 280 (5): 3125–8. doi:10.1074/jbc.C400496200. PMID 15590625.
  • Jönsson TJ, Murray MS, Johnson LC, et al. (2005). "Structural basis for the retroreduction of inactivated peroxiredoxins by human sulfiredoxin". Biochemistry. 44 (24): 8634–42. doi:10.1021/bi050131i. PMC 3928543. PMID 15952770.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Jeong W, Park SJ, Chang TS, et al. (2006). "Molecular mechanism of the reduction of cysteine sulfinic acid of peroxiredoxin to cysteine by mammalian sulfiredoxin". J. Biol. Chem. 281 (20): 14400–7. doi:10.1074/jbc.M511082200. PMID 16565085.
  • Findlay VJ, Townsend DM, Morris TE, et al. (2006). "A novel role for human sulfiredoxin in the reversal of glutathionylation". Cancer Res. 66 (13): 6800–6. doi:10.1158/0008-5472.CAN-06-0484. PMC 6361143. PMID 16818657.
  • v
  • t
  • e
  • 1xw3: Crystal Structure of Human Sulfiredoxin (Srx)
    1xw3: Crystal Structure of Human Sulfiredoxin (Srx)
  • 1xw4: Crystal Structure of Human Sulfiredoxin (Srx) in Complex with ADP
    1xw4: Crystal Structure of Human Sulfiredoxin (Srx) in Complex with ADP
  • 1yzs: Solution structure of human sulfiredoxin (srx)
    1yzs: Solution structure of human sulfiredoxin (srx)
  • 2b6f: Solution structure of human sulfiredoxin (SRX)
    2b6f: Solution structure of human sulfiredoxin (SRX)


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