SPEF1

Protein-coding gene in the species Homo sapiens
SPEF1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2EE7

Identifiers
AliasesSPEF1, C20orf28, CLAMP, SPEF1A, sperm flagellar 1
External IDsOMIM: 610674; MGI: 3513546; HomoloGene: 15741; GeneCards: SPEF1; OMA:SPEF1 - orthologs
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for SPEF1
Genomic location for SPEF1
Band20p13Start3,777,504 bp[1]
End3,781,448 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for SPEF1
Genomic location for SPEF1
Band2 F1|2Start131,012,181 bp[2]
End131,029,202 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right uterine tube

  • caudate nucleus

  • putamen

  • nucleus accumbens

  • bronchial epithelial cell

  • prefrontal cortex

  • hippocampus proper

  • Brodmann area 9

  • cingulate gyrus

  • inferior olivary nucleus
Top expressed in
  • olfactory epithelium

  • spermatocyte

  • spermatid

  • ganglionic eminence

  • saccule

  • right lung lobe

  • internal carotid artery

  • entorhinal cortex

  • corneal stroma

  • external carotid artery
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • microtubule binding
  • molecular function
Cellular component
  • cytoplasm
  • axoneme
  • cell projection
  • motile cilium
  • cilium
  • cytoskeleton
  • cellular component
Biological process
  • negative regulation of microtubule depolymerization
  • cell migration
  • biological process
  • cilium-dependent cell motility
  • regulation of cytoskeleton organization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

25876

70997

Ensembl

ENSG00000101222

ENSMUSG00000027329

UniProt

Q9Y4P9

Q99JL1

RefSeq (mRNA)

NM_015417

NM_027641

RefSeq (protein)

NP_056232

NP_081917

Location (UCSC)Chr 20: 3.78 – 3.78 MbChr 2: 131.01 – 131.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sperm flagellar protein 1 is a protein that in humans is encoded by the SPEF1 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101222 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027329 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chan SW, Fowler KJ, Choo KH, Kalitsis P (Jul 2005). "Spef1, a conserved novel testis protein found in mouse sperm flagella". Gene. 353 (2): 189–99. doi:10.1016/j.gene.2005.04.025. PMID 15979255.
  6. ^ "Entrez Gene: C20orf28 chromosome 20 open reading frame 28".

Further reading

  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Dougherty GW, Adler HJ, Rzadzinska A, et al. (2006). "CLAMP, a novel microtubule-associated protein with EB-type calponin homology". Cell Motil. Cytoskeleton. 62 (3): 141–56. doi:10.1002/cm.20093. PMID 16206169.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.


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