SNF8

Protein-coding gene in the species Homo sapiens
SNF8
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2ZME, 3CUQ

Identifiers
AliasesSNF8, Dot3, EAP30, VPS22, ESCRT-II complex subunit, SNF8 subunit of ESCRT-II
External IDsOMIM: 610904 MGI: 1343161 HomoloGene: 5239 GeneCards: SNF8
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for SNF8
Genomic location for SNF8
Band17q21.32Start48,929,316 bp[1]
End48,944,842 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for SNF8
Genomic location for SNF8
Band11 D|11 59.24 cMStart95,925,711 bp[2]
End95,938,256 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gastric mucosa

  • stromal cell of endometrium

  • left coronary artery

  • ganglionic eminence

  • right adrenal gland

  • popliteal artery

  • body of stomach

  • left adrenal gland

  • monocyte

  • ascending aorta
Top expressed in
  • yolk sac

  • morula

  • blastocyst

  • superior frontal gyrus

  • facial motor nucleus

  • duodenum

  • lip

  • thymus

  • anterior horn of spinal cord

  • jejunum
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein homodimerization activity
  • protein N-terminus binding
  • transcription factor binding
  • protein C-terminus binding
  • channel regulator activity
  • protein binding
Cellular component
  • cytoplasm
  • recycling endosome
  • cytosol
  • endosome
  • membrane
  • late endosome membrane
  • transcription regulator complex
  • plasma membrane
  • nucleoplasm
  • perinuclear region of cytoplasm
  • endosome membrane
  • extracellular exosome
  • nucleus
  • ESCRT II complex
Biological process
  • regulation of transcription, DNA-templated
  • positive regulation of protein catabolic process
  • multivesicular body sorting pathway
  • regulation of transcription by RNA polymerase II
  • multivesicular body assembly
  • regulation of multivesicular body size involved in endosome transport
  • transcription, DNA-templated
  • endosomal transport
  • regulation of protein complex stability
  • positive regulation of gene expression
  • early endosome to late endosome transport
  • endocytic recycling
  • regulation of protein catabolic process
  • protein transport
  • regulation of MAP kinase activity
  • positive regulation of exosomal secretion
  • protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
  • macroautophagy
  • regulation of molecular function
  • transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

11267

27681

Ensembl

ENSG00000159210

ENSMUSG00000006058

UniProt

Q96H20

Q9CZ28

RefSeq (mRNA)

NM_007241
NM_001317192
NM_001317193
NM_001317194

NM_033568
NM_001356362

RefSeq (protein)

NP_001304121
NP_001304122
NP_001304123
NP_009172

NP_291046
NP_001343291

Location (UCSC)Chr 17: 48.93 – 48.94 MbChr 11: 95.93 – 95.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Vacuolar-sorting protein SNF8 is a protein that in humans is encoded by the SNF8 gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000159210 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006058 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Schmidt AE; Miller T; Schmidt SL; Shiekhattar R; Shilatifard A (Aug 1999). "Cloning and characterization of the EAP30 subunit of the ELL complex that confers derepression of transcription by RNA polymerase II". J Biol Chem. 274 (31): 21981–5. doi:10.1074/jbc.274.31.21981. PMID 10419521.
  6. ^ Hierro A; Sun J; Rusnak AS; Kim J; Prag G; Emr SD; Hurley JH (Sep 2004). "Structure of the ESCRT-II endosomal trafficking complex". Nature. 431 (7005): 221–5. Bibcode:2004Natur.431..221H. doi:10.1038/nature02914. PMID 15329733. S2CID 4332050.
  7. ^ "Entrez Gene: SNF8 SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)".

Further reading

  • Kamura T, Burian D, Khalili H, et al. (2001). "Cloning and characterization of ELL-associated proteins EAP45 and EAP20. a role for yeast EAP-like proteins in regulation of gene expression by glucose". J. Biol. Chem. 276 (19): 16528–33. doi:10.1074/jbc.M010142200. PMID 11278625.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • von Schwedler UK, Stuchell M, Müller B, et al. (2003). "The protein network of HIV budding". Cell. 114 (6): 701–13. doi:10.1016/S0092-8674(03)00714-1. PMID 14505570. S2CID 16894972.
  • Martin-Serrano J, Yarovoy A, Perez-Caballero D, et al. (2003). "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12414–9. Bibcode:2003PNAS..10012414M. doi:10.1073/pnas.2133846100. PMC 218772. PMID 14519844.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Bowers K, Piper SC, Edeling MA, et al. (2006). "Degradation of endocytosed epidermal growth factor and virally ubiquitinated major histocompatibility complex class I is independent of mammalian ESCRTII". J. Biol. Chem. 281 (8): 5094–105. doi:10.1074/jbc.M508632200. PMID 16371348.
  • Langelier C, von Schwedler UK, Fisher RD, et al. (2006). "Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release". J. Virol. 80 (19): 9465–80. doi:10.1128/JVI.01049-06. PMC 1617254. PMID 16973552.


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