SNAPAP

SNAPIN
Identifiers
Aliases	SNAPIN, BLOC1S7, BLOS7, SNAPAP, BORCS3, SNAP associated protein
External IDs	OMIM: 607007; MGI: 1333745; HomoloGene: 8251; GeneCards: SNAPIN; OMA:SNAPIN - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 153,658,703 bp[1] End 153,661,852 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F1 Start 90,395,333 bp[2] End 90,398,340 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte myocardium of left ventricle secondary oocyte cardiac muscle tissue of right atrium Skeletal muscle tissue of biceps brachii tibialis anterior muscle apex of heart quadriceps femoris muscle right adrenal cortex vastus lateralis muscle Top expressed in cumulus cell temporal muscle muscle of thigh sternocleidomastoid muscle triceps brachii muscle utricle digastric muscle anterior horn of spinal cord quadriceps femoris muscle gastrocnemius muscle More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding SNARE binding Cellular component cytoplasm cytosol membrane synaptic vesicle BLOC-1 complex Golgi membrane synapse synaptic vesicle membrane secretory granule cell junction perinuclear region of cytoplasm cytoplasmic vesicle axon cytoplasm lysosome lysosomal membrane Golgi apparatus BORC complex Biological process negative regulation of neuron projection development positive regulation of late endosome to lysosome transport endosome to lysosome transport synaptic vesicle exocytosis synaptic vesicle fusion to presynaptic active zone membrane anterograde axonal transport melanosome organization autophagosome maturation synaptic vesicle transport terminal button organization anterograde synaptic vesicle transport intracellular protein transport viral process neuron projection development regulation of protein binding synaptic vesicle maturation neurotransmitter secretion exocytosis chemical synaptic transmission retrograde axonal transport late endosome to lysosome transport protein maturation lysosomal lumen acidification lysosome organization lysosome localization regulation of synaptic vesicle exocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23557 20615 Ensembl ENSG00000143553 ENSMUSG00000001018 UniProt O95295 Q9Z266 RefSeq (mRNA) NM_012437 NM_133854 RefSeq (protein) NP_036569 NP_598615 Location (UCSC) Chr 1: 153.66 – 153.66 Mb Chr 3: 90.4 – 90.4 Mb PubMed search [3] [4]
Wikidata
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SNARE-associated protein Snapin is a protein that in humans is encoded by the SNAPIN gene.^[5][6][7]

Function

SNAPAP is a component of the SNARE complex of proteins that is required for synaptic vesicle docking and fusion.^[5] SNAPAP is also a component of the ubiquitously expressed BLOC1 multisubunit protein complex. BLOC1 is required for normal biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules.^[7][8]

Snapin has been established to be a promoter of vesicle docking, as it plays a role in binding to SNAP-25, which together stabilize and favor SNARE complex assembly and vesicle docking.^[9] Specifically, the degree to which snapin is necessary for proper synaptic release varies across species. The functions of snapin have been reported to be independent of synaptotagmin, and works through the SNAP-25 pathway to stabilize, prime, and dock vesicles.^[9]

Interactions

SNAPAP has been shown to interact with:

References

Further reading