SH3PXD2A

Protein-coding gene in the species Homo sapiens
SH3PXD2A
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2DNU, 2EGA, 2EGC, 2EKH

Identifiers
AliasesSH3PXD2A, FISH, SH3MD1, TKS5, SH3 and PX domains 2A
External IDsMGI: 1298393 HomoloGene: 7317 GeneCards: SH3PXD2A
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for SH3PXD2A
Genomic location for SH3PXD2A
Band10q24.33Start103,594,027 bp[1]
End103,855,543 bp[1]
Gene location (Mouse)
Chromosome 19 (mouse)
Chr.Chromosome 19 (mouse)[2]
Chromosome 19 (mouse)
Genomic location for SH3PXD2A
Genomic location for SH3PXD2A
Band19|19 C3Start47,248,613 bp[2]
End47,452,840 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • cervix

  • sural nerve

  • trigeminal ganglion

  • tibia

  • inferior ganglion of vagus nerve

  • myometrium

  • vagina

  • cecum

  • tendon
Top expressed in
  • molar

  • ascending aorta

  • sciatic nerve

  • aortic valve

  • body of femur

  • belly cord

  • calvaria

  • skin of abdomen

  • utricle

  • brown adipose tissue
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
  • superoxide-generating NADPH oxidase activator activity
  • phosphatidylinositol binding
  • protease binding
  • phosphatidylinositol-4,5-bisphosphate binding
  • phosphatidylinositol-5-phosphate binding
  • phosphatidylinositol-3-phosphate binding
  • phosphatidylinositol-3,4-bisphosphate binding
  • phosphatidylinositol-4-phosphate binding
Cellular component
  • cytoplasm
  • podosome
  • cell junction
  • cell projection
  • cytosol
Biological process
  • osteoclast fusion
  • superoxide metabolic process
  • reactive oxygen species metabolic process
  • positive regulation of catalytic activity
  • podosome assembly
  • extracellular matrix organization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9644

14218

Ensembl

ENSG00000107957

ENSMUSG00000053617

UniProt

Q5TCZ1

O89032

RefSeq (mRNA)

NM_014631
NM_001365079

NM_001164717
NM_008018
NM_177833

RefSeq (protein)

NP_055446
NP_001352008

NP_001158189
NP_032044

Location (UCSC)Chr 10: 103.59 – 103.86 MbChr 19: 47.25 – 47.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

SH3 and PX domain-containing protein 2A is a protein that in humans is encoded by the SH3PXD2A gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000107957 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053617 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lock P, Abram CL, Gibson T, Courtneidge SA (Sep 1998). "A new method for isolating tyrosine kinase substrates used to identify fish, an SH3 and PX domain-containing protein, and Src substrate". EMBO J. 17 (15): 4346–57. doi:10.1093/emboj/17.15.4346. PMC 1170768. PMID 9687503.
  6. ^ "Entrez Gene: SH3PXD2A SH3 and PX domains 2A".

Further reading

  • Ishikawa K, Nagase T, Nakajima D, et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
  • Abram CL, Seals DF, Pass I, et al. (2003). "The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells". J. Biol. Chem. 278 (19): 16844–51. doi:10.1074/jbc.M300267200. PMID 12615925.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
  • Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
  • Seals DF, Azucena EF, Pass I, et al. (2005). "The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells". Cancer Cell. 7 (2): 155–65. doi:10.1016/j.ccr.2005.01.006. PMID 15710328.
  • Malinin NL, Wright S, Seubert P, et al. (2005). "Amyloid-beta neurotoxicity is mediated by FISH adapter protein and ADAM12 metalloprotease activity". Proc. Natl. Acad. Sci. U.S.A. 102 (8): 3058–63. Bibcode:2005PNAS..102.3058M. doi:10.1073/pnas.0408237102. PMC 549444. PMID 15710903.
  • Harold D, Jehu L, Turic D, et al. (2007). "Interaction between the ADAM12 and SH3MD1 genes may confer susceptibility to late-onset Alzheimer's disease". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 (4): 448–52. doi:10.1002/ajmg.b.30456. PMID 17440933. S2CID 13922599.


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