SFRP4

SFRP4
Identifiers
Aliases	SFRP4, FRP-4, FRPHE, sFRP-4, secreted frizzled related protein 4, PYL, FRZB-2
External IDs	OMIM: 606570; MGI: 892010; HomoloGene: 2267; GeneCards: SFRP4; OMA:SFRP4 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p14.1 Start 37,905,932 bp[1] End 38,025,695 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 A2|13 6.99 cM Start 19,807,274 bp[2] End 19,817,164 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube canal of the cervix vena cava tibial nerve spinal ganglia Achilles tendon smooth muscle tissue left uterine tube endometrium trigeminal ganglion Top expressed in ankle superior surface of tongue sciatic nerve uterus femur body of femur belly cord right ventricle utricle intercostal muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Wnt-protein binding G protein-coupled receptor activity Wnt-activated receptor activity Cellular component cytoplasm extracellular region cell surface nucleus extracellular space integral component of membrane Biological process cell differentiation positive regulation of keratinocyte apoptotic process positive regulation of receptor internalization positive regulation of canonical Wnt signaling pathway negative regulation of Wnt signaling pathway phosphate ion homeostasis Wnt signaling pathway negative regulation of DNA-binding transcription factor activity multicellular organism development negative regulation of sodium-dependent phosphate transport positive regulation of gene expression positive regulation of apoptotic process response to hormone positive regulation of epidermal cell differentiation negative regulation of cell population proliferation regulation of BMP signaling pathway bone morphogenesis negative regulation of canonical Wnt signaling pathway negative regulation of non-canonical Wnt signaling pathway G protein-coupled receptor signaling pathway non-canonical Wnt signaling pathway canonical Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6424 20379 Ensembl ENSG00000106483 ENSMUSG00000021319 UniProt Q6FHJ7 Q9Z1N6 RefSeq (mRNA) NM_003014 NM_016687 RefSeq (protein) NP_003005 NP_057896 Location (UCSC) Chr 7: 37.91 – 38.03 Mb Chr 13: 19.81 – 19.82 Mb PubMed search [3] [4]
Wikidata
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Secreted frizzled-related protein 4 is a protein that in humans is encoded by the SFRP4 gene.^[5][6]

Function

Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression.^[6]

Biallelic, recessive variants in the SFRP4 gene result in the genetic disorder of bone, Pyle disease,^[7] that is characterized by a failure of long bone remodeling with increased fragility. The association between SFRP4 deficiency and Pyle disease has highlighted the importance of SFRP4 in the formation of the bone cortex, and of the importance of bone cortex for the mechanical stability of long bone elements.

SFRP4 is a hub gene in a Type 2 Diabetes-associated gene coexpression module in human islets, and reduces glucose-induced insulin secretion through decreased β-cell exocytosis. Expression and release of SFRP4 from islets is enhanced by interleukin-1β. SFRP4 is elevated in serum several years before clinical diagnosis of Type 2 Diabetes. Individuals who have above-average levels of SFRP4 in the blood are five times more likely to develop diabetes in the next few years than those with below-average levels.^[8] SFRP4 concentration seems to correlate with obesity and systemic insulin resistance ^[9]

References

Further reading