SCH 900271

SCH 900271
Names
Preferred IUPAC name
5-[3-(1-Methylcyclopropyl)propyl]-2H-pyrano[2,3-d]pyrimidine-2,4,7(1H,3H)-trione
Identifiers
CAS Number
  • 915210-50-3 checkY
3D model (JSmol)
  • Interactive image
ChEMBL
  • ChEMBL2036958
ChemSpider
  • 28518389
DrugBank
  • DB12433
PubChem CID
  • 56950369
UNII
  • G2283XQ6VJ checkY
CompTox Dashboard (EPA)
  • DTXSID00238609 Edit this at Wikidata
InChI
  • InChI=1S/C14H16N2O4/c1-14(5-6-14)4-2-3-8-7-9(17)20-12-10(8)11(18)15-13(19)16-12/h7H,2-6H2,1H3,(H2,15,16,18,19)
    Key: ARJKMWXLIHZLQZ-UHFFFAOYSA-N
  • InChI=1/C14H16N2O4/c1-14(5-6-14)4-2-3-8-7-9(17)20-12-10(8)11(18)15-13(19)16-12/h7H,2-6H2,1H3,(H2,15,16,18,19)
    Key: ARJKMWXLIHZLQZ-UHFFFAOYAP
  • O=C1C=C(CCCC2(CC2)C)C(C(NC(N3)=O)=O)=C3O1
Properties
Chemical formula
 C14H16N2O4
Molar mass 276.292 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Chemical compound

SCH 900271 is a nicotinic acid derivative designed to treat dyslipidemia. It reduced plasma free fatty acids levels, but without significant flushing, a side effect common with niacin that limits its usefulness. SCH 900271 is currently in human trials.[1]

References

  1. ^ Palani, Anandan (November 2011). "Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia". ACS Medicinal Chemistry Letters. 3 (1): 63–8. doi:10.1021/ml200243g. PMC 4025820. PMID 24900372.


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