Philip Seeman

Canadian pharmacologist (1934–2021)

Philip Seeman
Born	(1934-02-08)8 February 1934 Winnipeg, Manitoba, Canada
Died	9 January 2021(2021-01-09) (aged 86) Toronto, Ontario, Canada
Awards	Order of Canada

Philip Seeman, OC FRSC (8 February 1934 – 9 January 2021) was a Canadian schizophrenia researcher and neuropharmacologist, known for his research on dopamine receptors.^[1]

Career

Born in Winnipeg, Manitoba, Seeman was raised in Montreal. He received a Bachelor of Science degree, honours physics & physiology (1955), a Master of Science degree, physiology of transport & secretion (1956), and a Doctor of Medicine (1960) from McGill University. In 1966, he received a Ph.D. in life sciences from Rockefeller University.

In 1967, Seeman became an assistant professor in the Department of Pharmacology at the University of Toronto. In 1970, he was appointed a professor.

In 1974, having spent years in search of the binding site of antipsychotic medication, he discovered the dopamine D2 receptor, the basis for the dopamine hypothesis of schizophrenia.^[2]^[3]

In 2001, he was made an Officer of the Order of Canada "for his research on dopamine receptors and their involvement in diseases such as schizophrenia, Parkinson's and Huntington's".^[4]

In 1985, he was made a Fellow of the Royal Society of Canada.^[5]

He was married to Dr. Mary V. Seeman.^[6]

Notes

^ "Philip SEEMAN". The Globe and Mail. Retrieved 19 January 2021.
^ P. Seeman, M. Chau-Wong, J. Tedesco & K. Wong (November 1975). "Brain receptors for antipsychotic drugs and dopamine: direct binding assays". Proceedings of the National Academy of Sciences of the United States of America. 72 (11): 4376–4370. Bibcode:1975PNAS...72.4376S. doi:10.1073/pnas.72.11.4376. PMC 388724. PMID 1060115.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ "People". CMAJ. 151 (8): 1186–1187. 1994. PMC 1337253.
^ Order of Canada citation
^ "Science & Medicine - Science & Medicine". www.sciandmed.com. Archived from the original on 2011-07-16.
^ "Most Wikipedia profiles are about men – these women in Australia are hoping to change that". SBS News. Retrieved 27 July 2019.

References

Madras, B.K. (2013). "History of the discovery of the antipsychotic dopamine D2 receptor: A basis for the dopamine hypothesis of schizophrenia". Journal of the History of the Neurosciences: Basic and Clinical Perspectives. 22 (1): 62–78. doi:10.1080/0964704x.2012.678199. PMID 23323533. S2CID 12002684.
Seeman, P. (2011). "All roads to schizophrenia lead to dopamine supersensitivity and elevated dopamine D2High receptors". CNS Neuroscience & Therapeutics. 17 (2): 118–132. doi:10.1111/j.1755-5949.2010.00162.x. PMC 6493870. PMID 20560996.
P. Seeman (2010). "Dopamine D2 Receptors as Treatment Targets in Schizophrenia. Clinical Schizophrenia & Related Psychoses April: 56-73.
P. Seeman (2007), Scholarpedia, 2(10): 3634 doi.4249/scholarpedia.3634
Seeman, P. (2006). "Targeting the dopamine D2 receptor in schizophrenia". Expert Opinion on Therapeutic Targets. 10 (4): 515–531. doi:10.1517/14728222.10.4.515. PMID 16848689. S2CID 30902536.
Seeman, P.; Weinshenker, D.; Quirion, R.; Srivastava, L.; Bhardwaj, S.K.; Grandy, D.K.; Premont, R.; Sotnikova, T.; Boksa, P.; El-Ghundi, M.; O'Dowd, B.F.; George, S.R.; Perreault, M.L.; Mannisto, P.T.; Robinson, S.; Palmiter, R.D.; Tallerico, T. (2005). "Dopamine supersensitivity correlates with D2High states, implying many paths to psychosis". Proceedings of the National Academy of Sciences USA. 102 (9): 3513–3518. Bibcode:2005PNAS..102.3513S. doi:10.1073/pnas.0409766102. PMC 548961. PMID 15716360.
Seeman, P.; Chau-Wong, M.; Tedesco, J.; Wong, K. (1975). "Brain receptors for antipsychotic drugs and dopamine: Direct binding assays". Proceedings of the National Academy of Sciences, USA. 72 (11): 4376–4380. Bibcode:1975PNAS...72.4376S. doi:10.1073/pnas.72.11.4376. PMC 388724. PMID 1060115.

External links

Home Page of Philip Seeman's Laboratory
Probing the Biology of Psychosis, Schizophrenia, and Antipsychotics: An Expert Interview With Dr. Philip Seeman, MD, PhD – an interview on the Medscape website
Schizophrenia – an essay by Philip Seeman, November 2001