Nucleoporin 205

Protein-coding gene in the species Homo sapiens

NUP205

Available structures

PDB

Human UniProt search: PDBe RCSB

List of PDB id codes
5IJN, 5IJO

Identifiers

Aliases

NUP205, C7orf14, NPHS13, nucleoporin 205kDa, nucleoporin 205

External IDs

OMIM: 614352; MGI: 2141625; HomoloGene: 45971; GeneCards: NUP205; OMA:NUP205 - orthologs

Gene location (Human)

Chr.	Chromosome 7 (human)^[1]

Band	7q33	Start	135,557,917 bp^[1]
Band	7q33	End	135,648,757 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 6 (mouse)^[2]

Band	6\|6 B1	Start	35,154,356 bp^[2]
Band	6\|6 B1	End	35,224,531 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

ventricular zone

ganglionic eminence

secondary oocyte

anterior pituitary

gonad

skin of abdomen

ectocervix

skin of leg

mucosa of transverse colon

left uterine tube

Top expressed in

spermatocyte

hand

primitive streak

spermatid

seminiferous tubule

maxillary prominence

abdominal wall

mandibular prominence

epiblast

endothelial cell of lymphatic vessel

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	structural constituent of nuclear pore protein binding
Cellular component	nuclear membrane nuclear envelope membrane nuclear periphery nuclear pore inner ring nuclear pore nucleus host cell
Biological process	mRNA transport nuclear pore complex assembly viral transcription protein sumoylation mitotic nuclear membrane disassembly nucleocytoplasmic transport regulation of cellular response to heat protein transport viral process intracellular transport of virus tRNA export from nucleus mRNA export from nucleus regulation of gene silencing by miRNA regulation of glycolytic process transport nuclear pore organization
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


23165


70699

Ensembl


ENSG00000155561


ENSMUSG00000038759

UniProt


Q92621


n/a

RefSeq (mRNA)


NM_015135 NM_001329434


NM_027513

RefSeq (protein)


NP_001316363 NP_055950


n/a

Location (UCSC)

Chr 7: 135.56 – 135.65 Mb

Chr 6: 35.15 – 35.22 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Nucleoporin 205 (Nup205) is a protein that in humans is encoded by the NUP205 gene.^[5]^[6]^[7]

Function

Transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPC's are composed of subcomplexes, and NUP205 is part of one such subcomplex.^[5] It has also been recently shown that Nup205 is required for proper viral gene expression.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000155561 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038759 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: NUP205 nucleoporin 205kDa".
^ Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (October 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
^ Grandi P, Dang T, Pané N, Shevchenko A, Mann M, Forbes D, Hurt E (October 1997). "Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assembly". Mol. Biol. Cell. 8 (10): 2017–38. doi:10.1091/mbc.8.10.2017. PMC 25664. PMID 9348540.
^ Lu Y, Kucharski TJ, Gamache I, Blanchette P, Branton PE, Teodoro JG (Nov 2014). "Interaction of adenovirus type 5 E4orf4 with the nuclear pore subunit Nup205 is required for proper viral gene expression". J Virol. 88 (22): 13249–59. doi:10.1128/JVI.00933-14. PMC 4249058. PMID 25210169.

Hawryluk-Gara LA, Shibuya EK, Wozniak RW (2005). "Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex". Mol. Biol. Cell. 16 (5): 2382–94. doi:10.1091/mbc.E04-10-0857. PMC 1087243. PMID 15703211.
Grandi P, Dang T, Pané N, Shevchenko A, Mann M, Forbes D, Hurt E (1997). "Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assembly". Mol. Biol. Cell. 8 (10): 2017–38. doi:10.1091/mbc.8.10.2017. PMC 25664. PMID 9348540.
Le Rouzic E, Mousnier A, Rustum C, Stutz F, Hallberg E, Dargemont C, Benichou S (2002). "Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1". J. Biol. Chem. 277 (47): 45091–8. doi:10.1074/jbc.M207439200. PMID 12228227.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Hase ME, Cordes VC (2003). "Direct interaction with nup153 mediates binding of Tpr to the periphery of the nuclear pore complex". Mol. Biol. Cell. 14 (5): 1923–40. doi:10.1091/mbc.E02-09-0620. hdl:11858/00-001M-0000-0028-3D33-F. PMC 165087. PMID 12802065.
Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
Sowa ME, Bennett EJ, Gygi SP, Harper JW (2009). "Defining the human deubiquitinating enzyme interaction landscape". Cell. 138 (2): 389–403. doi:10.1016/j.cell.2009.04.042. PMC 2716422. PMID 19615732.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.