Milataxel
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IUPAC name (2α,5β,7β,10β,13α)-4-Acetoxy-13-{[(2R,3R)-3-(2-furyl)-2-hydroxy-3-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)propanoyl]oxy}-1,10-dihydroxy-9-oxo-7-(propionyloxy)-5,20-epoxytax-11-en-2-yl benzoate | |
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Chemical formula | C44H55NO16 |
Molar mass | 853.905 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references |
Chemical compound
Milataxel (MAC-321, TL-139) is a taxol analog.[1][2]
References
- ^ Safarpour, H; Connolly, P; Tong, X; Bielawski, M; Wilcox, E (2009). "Overcoming extractability hurdles of a 14C labeled taxane analogue milataxel and its metabolite from xenograft mouse tumor and brain tissues". Journal of Pharmaceutical and Biomedical Analysis. 49 (3): 774–9. doi:10.1016/j.jpba.2008.12.034. PMID 19186016.
- ^ Sampath, D; Discafani, CM; Loganzo, F; Beyer, C; Liu, H; Tan, X; Musto, S; Annable, T; Gallagher, P; Rios, C; Greenberger, LM (2003). "MAC-321, a novel taxane with greater efficacy than paclitaxel and docetaxel in vitro and in vivo". Molecular Cancer Therapeutics. 2 (9): 873–84. PMID 14555706.
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