MSRB2

Protein-coding gene in the species Homo sapiens
MSRB2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2L1U

Identifiers
AliasesMSRB2, CBS-1, CBS1, MSRB, PILB, CGI-131, methionine sulfoxide reductase B2
External IDsOMIM: 613782; MGI: 1923717; HomoloGene: 56555; GeneCards: MSRB2; OMA:MSRB2 - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for MSRB2
Genomic location for MSRB2
Band10p12.2Start23,095,579 bp[1]
End23,122,013 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for MSRB2
Genomic location for MSRB2
Band2|2 A3Start19,376,251 bp[2]
End19,399,787 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right ventricle

  • apex of heart

  • vena cava

  • left ventricle

  • right auricle

  • Skeletal muscle tissue of rectus abdominis

  • muscle of arm

  • biceps brachii

  • triceps brachii muscle

  • Skeletal muscle tissue of biceps brachii
Top expressed in
  • interventricular septum

  • myocardium of ventricle

  • right kidney

  • cardiac muscles

  • granulocyte

  • right ventricle

  • lumbar spinal ganglion

  • proximal tubule

  • cervix

  • skeletal muscle tissue
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • DNA-binding transcription factor activity
  • oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
  • oxidoreductase activity
  • actin binding
  • zinc ion binding
  • metal ion binding
  • peptide-methionine (R)-S-oxide reductase activity
  • L-methionine-(R)-S-oxide reductase activity
Cellular component
  • cytosol
  • mitochondrion
Biological process
  • actin filament polymerization
  • response to oxidative stress
  • protein repair
  • regulation of transcription, DNA-templated
  • cellular response to oxidative stress
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

22921

76467

Ensembl

ENSG00000148450

ENSMUSG00000023094

UniProt

Q9Y3D2

Q78J03

RefSeq (mRNA)

NM_012228

NM_029619

RefSeq (protein)

NP_036360

NP_083895

Location (UCSC)Chr 10: 23.1 – 23.12 MbChr 2: 19.38 – 19.4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Methionine-R-sulfoxide reductase B2, mitochondrial is an enzyme that in humans is encoded by the MSRB2 gene.[5][6][7] The MRSB2 enzyme catalyzes the reduction of methionine sulfoxide to methionine.


See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000148450 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023094 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Escribano J, Ortego J, Coca-Prados M (Jan 1997). "Isolation and characterization of cell-specific cDNA clones from a subtractive library of the ocular ciliary body of a single normal human donor: transcription and synthesis of plasma proteins". J Biochem. 118 (5): 921–31. doi:10.1093/jb/118.5.921. PMID 8749308.
  6. ^ Huang W, Escribano J, Sarfarazi M, Coca-Prados M (Aug 1999). "Identification, expression and chromosome localization of a human gene encoding a novel protein with similarity to the pilB family of transcriptional factors (pilin) and to bacterial peptide methionine sulfoxide reductases". Gene. 233 (1–2): 233–40. doi:10.1016/S0378-1119(99)00131-6. PMID 10375640.
  7. ^ "Entrez Gene: MSRB2 methionine sulfoxide reductase B2".

Further reading

  • Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
  • Jung S, Hansel A, Kasperczyk H, et al. (2002). "Activity, tissue distribution and site-directed mutagenesis of a human peptide methionine sulfoxide reductase of type B: hCBS1". FEBS Lett. 527 (1–3): 91–4. doi:10.1016/S0014-5793(02)03171-X. PMID 12220640. S2CID 2170229.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Kim HY, Gladyshev VN (2004). "Methionine sulfoxide reduction in mammals: characterization of methionine-R-sulfoxide reductases". Mol. Biol. Cell. 15 (3): 1055–64. doi:10.1091/mbc.E03-08-0629. PMC 363075. PMID 14699060.
  • Picot CR, Perichon M, Cintrat JC, et al. (2004). "The peptide methionine sulfoxide reductases, MsrA and MsrB (hCBS-1), are downregulated during replicative senescence of human WI-38 fibroblasts". FEBS Lett. 558 (1–3): 74–8. doi:10.1016/S0014-5793(03)01530-8. PMID 14759519. S2CID 32573388.
  • Hansel A, Jung S, Hoshi T, Heinemann SH (2004). "A second human methionine sulfoxide reductase (hMSRB2) reducing methionine-R-sulfoxide displays a tissue expression pattern distinct from hMSRB1". Redox Rep. 8 (6): 384–8. doi:10.1179/135100003225003429. PMID 14980072.
  • Schallreuter KU, Rübsam K, Chavan B, et al. (2006). "Functioning methionine sulfoxide reductases A and B are present in human epidermal melanocytes in the cytosol and in the nucleus". Biochem. Biophys. Res. Commun. 342 (1): 145–52. doi:10.1016/j.bbrc.2006.01.124. PMID 16480945.


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