MRPS6

Protein-coding gene in the species Homo sapiens
MRPS6
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3J9M

Identifiers
AliasesMRPS6, C21orf101, MRP-S6, RPMS6, S6mt, mitochondrial ribosomal protein S6
External IDsOMIM: 611973 MGI: 2153111 HomoloGene: 41871 GeneCards: MRPS6
Gene location (Human)
Chromosome 21 (human)
Chr.Chromosome 21 (human)[1]
Chromosome 21 (human)
Genomic location for MRPS6
Genomic location for MRPS6
Band21q22.11Start34,073,224 bp[1]
End34,143,034 bp[1]
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[2]
Chromosome 16 (mouse)
Genomic location for MRPS6
Genomic location for MRPS6
Band16|16 C4Start91,855,158 bp[2]
End91,909,115 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • renal medulla

  • left lobe of thyroid gland

  • kidney

  • right lobe of thyroid gland

  • right coronary artery

  • tibial nerve

  • spinal ganglia

  • trigeminal ganglion

  • ascending aorta

  • Achilles tendon
Top expressed in
  • retinal pigment epithelium

  • ciliary body

  • medullary collecting duct

  • sciatic nerve

  • iris

  • renal corpuscle

  • condyle

  • calvaria

  • fossa

  • white adipose tissue
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • structural constituent of ribosome
  • rRNA binding
  • protein binding
  • small ribosomal subunit rRNA binding
Cellular component
  • small ribosomal subunit
  • mitochondrial inner membrane
  • ribosome
  • mitochondrial small ribosomal subunit
  • mitochondrion
Biological process
  • mitochondrial translational elongation
  • mitochondrial translational termination
  • protein biosynthesis
  • mitochondrial translation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

64968

121022

Ensembl

ENSG00000243927

ENSMUSG00000039680

UniProt

P82932

P58064

RefSeq (mRNA)

NM_032476

NM_080456

RefSeq (protein)

NP_115865

NP_536704

Location (UCSC)Chr 21: 34.07 – 34.14 MbChr 16: 91.86 – 91.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

28S ribosomal protein S6, mitochondrial is a protein that in humans is encoded by the MRPS6 gene.[5]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S6P family. Pseudogenes corresponding to this gene are found on chromosomes 1p and 12q.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000243927 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039680 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: MRPS6 mitochondrial ribosomal protein S6".

Further reading

  • Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
  • Cavdar Koc E, Burkhart W, Blackburn K, et al. (2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J. Biol. Chem. 276 (22): 19363–74. CiteSeerX 10.1.1.501.8919. doi:10.1074/jbc.M100727200. PMID 11279123.
  • Suzuki T, Terasaki M, Takemoto-Hori C, et al. (2001). "Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit". J. Biol. Chem. 276 (35): 33181–95. doi:10.1074/jbc.M103236200. PMID 11402041.
  • Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
  • Reymond A, Camargo AA, Deutsch S, et al. (2002). "Nineteen additional unpredicted transcripts from human chromosome 21". Genomics. 79 (6): 824–32. doi:10.1006/geno.2002.6781. PMID 12036297.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

  • Overview of all the structural information available in the PDB for UniProt: P82932 (28S ribosomal protein S6, mitochondrial) at the PDBe-KB.
  • v
  • t
  • e
Proteins
Initiation factor
Bacterial
Mitochondrial
Archaeal
  • aIF1
  • aIF2
  • aIF5
  • aIF6
Eukaryotic
eIF1
eIF2
eIF3
eIF4
eIF5
eIF6
Elongation factor
Bacterial/​Mitochondrial
Archaeal/​Eukaryotic
Release factor
Ribosomal Proteins
Cytoplasmic
60S subunit
40S subunit
Mitochondrial
39S subunit
28S subunit
Other concepts
Stub icon

This article on a gene on human chromosome 21 is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e
Stub icon

This protein-related article is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e