MMP24

Protein-coding gene in the species Homo sapiens

MMP24

Identifiers

Aliases

MMP24, MMP-24, MMP25, MT-MMP 5, MT-MMP5, MT5-MMP, MT5MMP, MTMMP5, matrix metallopeptidase 24

External IDs

OMIM: 604871 MGI: 1341867 HomoloGene: 21331 GeneCards: MMP24

Gene location (Human)

Chr.	Chromosome 20 (human)^[1]

Band	20q11.22	Start	35,226,690 bp^[1]
Band	20q11.22	End	35,276,998 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2 H1\|2 77.26 cM	Start	155,617,262 bp^[2]
Band	2 H1\|2 77.26 cM	End	155,660,286 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

cerebellar vermis

internal globus pallidus

prefrontal cortex

ganglionic eminence

endothelial cell

synovial joint

cingulate gyrus

occipital lobe

nucleus accumbens

Brodmann area 9

Top expressed in

cerebellar cortex

cerebellar vermis

supraoptic nucleus

superior frontal gyrus

ganglionic eminence

ascending aorta

aortic valve

substantia nigra

trigeminal ganglion

barrel cortex

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	zinc ion binding cadherin binding metal ion binding peptidase activity enzyme activator activity metalloendopeptidase activity hydrolase activity metallopeptidase activity
Cellular component	integral component of membrane Golgi apparatus trans-Golgi network membrane membrane extracellular matrix plasma membrane integral component of plasma membrane extracellular region extracellular exosome extracellular space
Biological process	glial cell differentiation proteolysis detection of temperature stimulus involved in sensory perception of pain neuronal stem cell population maintenance cell-cell adhesion mediated by cadherin cell adhesion positive regulation of catalytic activity cell-cell adhesion via plasma-membrane adhesion molecules extracellular matrix organization collagen catabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


10893


17391

Ensembl


ENSG00000125966


ENSMUSG00000027612

UniProt


Q9Y5R2


Q9R0S2

RefSeq (mRNA)


NM_006690


NM_010808

RefSeq (protein)


NP_006681


NP_034938

Location (UCSC)

Chr 20: 35.23 – 35.28 Mb

Chr 2: 155.62 – 155.66 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Matrix metalloproteinase-24 is an enzyme that in humans is encoded by the MMP24 gene.^[5]^[6]

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed MMP24.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125966 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027612 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Llano E, Pendas AM, Freije JP, Nakano A, Knauper V, Murphy G, Lopez-Otin C (Jun 1999). "Identification and characterization of human MT5-MMP, a new membrane-bound activator of progelatinase a overexpressed in brain tumors". Cancer Res. 59 (11): 2570–6. PMID 10363975.
^ ^a ^b "Entrez Gene: MMP24 matrix metallopeptidase 24 (membrane-inserted)".

Nagase H, Woessner JF (1999). "Matrix metalloproteinases". J. Biol. Chem. 274 (31): 21491–4. doi:10.1074/jbc.274.31.21491. PMID 10419448.
Kinoh H, Hayashita H, Kajita M, et al. (2000). "Assignment of the genes for membrane-type-4 matrix metalloproteinase (Mmp17, MMP17) to mouse chromosome 5, human chromosome band 12q24.3 and membrane-type-5 matrix metalloproteinase (Mmp24, MMP24) to mouse chromosome 2 and human chromosome band 20q11.2→q12, respectively, by radiation hybrid and in situ hybridization". Cytogenet. Cell Genet. 87 (1–2): 97–8. doi:10.1159/000015402. PMID 10640822. S2CID 24060884.
Romanic AM, Burns-Kurtis CL, Ao Z, et al. (2001). "Upregulated expression of human membrane type-5 matrix metalloproteinase in kidneys from diabetic patients". Am. J. Physiol. Renal Physiol. 281 (2): F309–17. doi:10.1152/ajprenal.2001.281.2.F309. PMID 11457723. S2CID 5735565.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Jung M, Römer A, Keyszer G, et al. (2003). "mRNA expression of the five membrane-type matrix metalloproteinases MT1-MT5 in human prostatic cell lines and their down-regulation in human malignant prostatic tissue". Prostate. 55 (2): 89–98. doi:10.1002/pros.10194. PMID 12661033. S2CID 21596144.
Takino T, Koshikawa N, Miyamori H, et al. (2003). "Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases". Oncogene. 22 (30): 4617–26. doi:10.1038/sj.onc.1206542. hdl:2297/2668. PMID 12879005. S2CID 10007952.
Wang P, Wang X, Pei D (2004). "Mint-3 regulates the retrieval of the internalized membrane-type matrix metalloproteinase, MT5-MMP, to the plasma membrane by binding to its carboxyl end motif EWV". J. Biol. Chem. 279 (19): 20461–70. doi:10.1074/jbc.M400264200. PMID 14990567.
Gaetje R, Holtrich U, Engels K, et al. (2008). "Expression of membrane-type 5 matrix metalloproteinase in human endometrium and endometriosis". Gynecol. Endocrinol. 23 (10): 567–73. doi:10.1080/09513590701556921. PMID 17952761. S2CID 25621136.