L3MBTL

Lethal(3)malignant brain tumor-like protein
L3MBTL1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1OYX, 1OZ2, 1OZ3, 2PQW, 2RHI, 2RHU, 2RHX, 2RHY, 2RHZ, 2RI2, 2RI3, 2RI5, 2RJC, 2RJD, 2RJE, 2RJF, 3OQ5, 3P8H, 3UWN

Identifiers
AliasesL3MBTL1, H-L(3)MBT, L3MBTL, ZC2HC3, dJ138B7.3, l(3)mbt-like 1 (Drosophila), histone methyl-lysine binding protein, L3MBTL histone methyl-lysine binding protein 1
External IDsOMIM: 608802; MGI: 2676663; HomoloGene: 41846; GeneCards: L3MBTL1; OMA:L3MBTL1 - orthologs
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for L3MBTL1
Genomic location for L3MBTL1
Band20q13.12Start43,489,442 bp[1]
End43,550,950 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for L3MBTL1
Genomic location for L3MBTL1
Band2|2 H2Start162,943,472 bp[2]
End162,974,522 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pituitary gland

  • anterior pituitary

  • subthalamic nucleus

  • right uterine tube

  • tongue

  • superior surface of tongue

  • superior vestibular nucleus

  • hypothalamus

  • striated muscle tissue

  • skeletal muscle tissue
Top expressed in
  • hypothalamus

  • respiratory epithelium

  • female urethra

  • olfactory epithelium

  • superior frontal gyrus

  • ureter

  • cerebellum

  • cerebellar cortex

  • spinal ganglia

  • secondary oocyte
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • DNA-binding transcription factor activity
  • histone binding
  • zinc ion binding
  • SAM domain binding
  • chromatin binding
  • metal ion binding
  • methylated histone binding
  • protein binding
  • identical protein binding
  • nucleosome binding
Cellular component
  • plasma membrane
  • nucleolus
  • chromatin
  • condensed chromosome
  • nucleus
  • nucleoplasm
Biological process
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • regulation of cell cycle
  • negative regulation of transcription, DNA-templated
  • regulation of megakaryocyte differentiation
  • regulation of mitotic nuclear division
  • regulation of signal transduction by p53 class mediator
  • chromatin organization
  • hemopoiesis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26013

241764

Ensembl

ENSG00000185513

ENSMUSG00000035576

UniProt

Q9Y468

A2A5N8

RefSeq (mRNA)

NM_032107
NM_015478

NM_001081338

RefSeq (protein)

NP_056293
NP_115479

NP_001074807

Location (UCSC)Chr 20: 43.49 – 43.55 MbChr 2: 162.94 – 162.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Lethal(3)malignant brain tumor-like protein is a protein that in humans is encoded by the L3MBTL gene.[5][6][7]

This gene encodes the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion mother cells in the optic centers of the brain. This gene product is localized to condensed chromosomes in mitotic cells. Overexpression of this gene in a glioma cell line results in improper nuclear segregation and cytokinesis producing multinucleated cells. Alternatively spliced transcript variants encoding different isoforms have been identified.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000185513 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035576 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Koga H, Matsui S, Hirota T, Takebayashi S, Okumura K, Saya H (Sep 1999). "A human homolog of Drosophila lethal(3)malignant brain tumor (l(3)mbt) protein associates with condensed mitotic chromosomes". Oncogene. 18 (26): 3799–809. doi:10.1038/sj.onc.1202732. PMID 10445843. S2CID 8186230.
  6. ^ Trojer P, Li G, Sims RJ III, Vaquero A, Kalakonda N, Boccuni P, Lee D, Erdjument-Bromage H, Tempst P, Nimer SD, Wang YH, Reinberg D (Jun 2007). "L3MBTL1, a histone-methylation-dependent chromatin lock". Cell. 129 (5): 915–28. doi:10.1016/j.cell.2007.03.048. PMID 17540172. S2CID 16425537.
  7. ^ a b "Entrez Gene: L3MBTL l(3)mbt-like (Drosophila)".

Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • MacGrogan D, Kalakonda N, Alvarez S, et al. (2004). "Structural integrity and expression of the L3MBTL gene in normal and malignant hematopoietic cells". Genes Chromosomes Cancer. 41 (3): 203–13. doi:10.1002/gcc.20087. PMID 15334543. S2CID 35563365.
  • Li J, Bench AJ, Vassiliou GS, et al. (2004). "Imprinting of the human L3MBTL gene, a polycomb family member located in a region of chromosome 20 deleted in human myeloid malignancies". Proc. Natl. Acad. Sci. U.S.A. 101 (19): 7341–6. Bibcode:2004PNAS..101.7341L. doi:10.1073/pnas.0308195101. PMC 409920. PMID 15123827.
  • Wang WK, Tereshko V, Boccuni P, et al. (2004). "Malignant brain tumor repeats: a three-leaved propeller architecture with ligand/peptide binding pockets". Structure. 11 (7): 775–89. doi:10.1016/S0969-2126(03)00127-8. PMC 4693639. PMID 12842041.
  • Boccuni P, MacGrogan D, Scandura JM, Nimer SD (2003). "The human L(3)MBT polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6)". J. Biol. Chem. 278 (17): 15412–20. doi:10.1074/jbc.M300592200. PMID 12588862.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
  • Fossey SC, Mychaleckyj JC, Pendleton JK, et al. (2001). "A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20". Genomics. 76 (1–3): 45–57. doi:10.1006/geno.2001.6584. PMID 11549316.
  • Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
  • Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.

External links

  • Overview of all the structural information available in the PDB for UniProt: Q9Y468 (Lethal(3)malignant brain tumor-like protein 1) at the PDBe-KB.
  • v
  • t
  • e
  • 1oyx: CRYSTAL STRUCTURE OF 3-MBT REPEATS OF LETHAL (3) MALIGNANT BRAIN TUMOR (SELENO-MET) AT 1.85 ANGSTROM
    1oyx: CRYSTAL STRUCTURE OF 3-MBT REPEATS OF LETHAL (3) MALIGNANT BRAIN TUMOR (SELENO-MET) AT 1.85 ANGSTROM
  • 1oz2: CRYSTAL STRUCTURE OF 3-MBT REPEATS OF LETHAL (3) MALIGNANT BRAIN TUMOR (NATIVE-II) AT 1.55 ANGSTROM
    1oz2: CRYSTAL STRUCTURE OF 3-MBT REPEATS OF LETHAL (3) MALIGNANT BRAIN TUMOR (NATIVE-II) AT 1.55 ANGSTROM
  • 1oz3: Crystal Structure of 3-MBT repeats of lethal (3) malignant Brain Tumor (Native-I) at 1.85 angstrom
    1oz3: Crystal Structure of 3-MBT repeats of lethal (3) malignant Brain Tumor (Native-I) at 1.85 angstrom


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