KIF17

Protein-coding gene in the species Homo sapiens
KIF17
Identifiers
AliasesKIF17, Kif17, 5930435E01Rik, AW492270, Kif17b, mKIAA1405, KIF3X, KLP-2, OSM-3, kinesin family member 17
External IDsOMIM: 605037; MGI: 1098229; HomoloGene: 5883; GeneCards: KIF17; OMA:KIF17 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for KIF17
Genomic location for KIF17
Band1p36.12Start20,664,014 bp[1]
End20,718,017 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for KIF17
Genomic location for KIF17
Band4|4 D3Start137,977,746 bp[2]
End138,029,278 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left testis

  • right testis

  • right adrenal cortex

  • left adrenal gland

  • spleen

  • left adrenal cortex

  • right frontal lobe

  • prefrontal cortex

  • testicle

  • apex of heart
Top expressed in
  • primary oocyte

  • zygote

  • seminiferous tubule

  • secondary oocyte

  • spermatid

  • superior frontal gyrus

  • visual cortex

  • primary visual cortex

  • lumbar subsegment of spinal cord

  • dorsal striatum
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • nucleotide binding
  • microtubule motor activity
  • microtubule binding
  • plus-end-directed microtubule motor activity
  • ATP binding
  • ATPase activity
Cellular component
  • intraciliary transport particle B
  • cytoplasm
  • ciliary basal body
  • cytosol
  • kinesin complex
  • microtubule cytoskeleton
  • photoreceptor connecting cilium
  • periciliary membrane compartment
  • axoneme
  • microtubule
  • cytoskeleton
  • cell projection
  • cilium
  • dendrite cytoplasm
  • neuron projection
Biological process
  • microtubule-based movement
  • cell projection organization
  • microtubule-based process
  • protein transport
  • protein-containing complex localization
  • vesicle-mediated transport
  • neurogenesis
  • intraciliary transport involved in cilium assembly
  • anterograde dendritic transport of neurotransmitter receptor complex
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

57576

16559

Ensembl

ENSG00000117245

ENSMUSG00000028758

UniProt

Q9P2E2

Q99PW8

RefSeq (mRNA)

NM_001122819
NM_001287212
NM_020816

NM_001190978
NM_010623

RefSeq (protein)

NP_001116291
NP_001274141
NP_065867

NP_001177907
NP_034753

Location (UCSC)Chr 1: 20.66 – 20.72 MbChr 4: 137.98 – 138.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Kinesin-like protein KIF17 is a protein that in humans is encoded by the KIF17 gene.[5][6] KIF17 and its close relative, C. elegans OSM-3,[7] are members of the kinesin-2 family of plus-end directed microtubule-based motor proteins.[8] In contrast to heterotrimeric kinesin-2 motors,[9] however, KIF17 and OSM-3 form distinct homodimeric complexes.[10] Homodimeric kinesin-2 has been implicated in the transport of NMDA receptors along dendrites for delivery to the dendritic membrane,[5] whereas both heterotrimeric and homodimeric kinesin-2 motors function cooperatively in anterograde intraflagellar transport (IFT) and cilium biogenesis.[11][12]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000117245 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028758 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Setou M, Nakagawa T, Seog DH, Hirokawa N (Jun 2000). "Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport". Science. 288 (5472): 1796–802. Bibcode:2000Sci...288.1796S. doi:10.1126/science.288.5472.1796. PMID 10846156.
  6. ^ "Entrez Gene: KIF17 kinesin family member 17".
  7. ^ Shakir MA, Fukushige T, Yasuda H, Miwa J, Siddiqui SS (July 1993). "C. elegans osm-3 gene mediating osmotic avoidance behaviour encodes a kinesin-like protein". NeuroReport. 4 (7): 891–4. doi:10.1097/00001756-199307000-00013. PMID 7690265.
  8. ^ Lawrence CJ, Dawe RK, Christie KR, Cleveland DW, Dawson SC, Endow SA, Goldstein LS, Goodson HV, Hirokawa N, Howard J, Malmberg RL, McIntosh JR, Miki H, Mitchison TJ, Okada Y, Reddy AS, Saxton WM, Schliwa M, Scholey JM, Vale RD, Walczak CE, Wordeman L (October 2004). "A standardized kinesin nomenclature". J. Cell Biol. 167 (1): 19–22. doi:10.1083/jcb.200408113. PMC 2041940. PMID 15479732.
  9. ^ Cole DG, Chinn SW, Wedaman KP, Hall K, Vuong T, Scholey JM (November 1993). "Novel heterotrimeric kinesin-related protein purified from sea urchin eggs". Nature. 366 (6452): 268–70. Bibcode:1993Natur.366..268C. doi:10.1038/366268a0. PMID 8232586. S2CID 4367715.
  10. ^ Signor D, Wedaman KP, Rose LS, Scholey JM (February 1999). "Two heteromeric kinesin complexes in chemosensory neurons and sensory cilia of Caenorhabditis elegans". Mol. Biol. Cell. 10 (2): 345–60. doi:10.1091/mbc.10.2.345. PMC 25173. PMID 9950681.
  11. ^ Snow JJ, Ou G, Gunnarson AL, Walker MR, Zhou HM, Brust-Mascher I, Scholey JM (November 2004). "Two anterograde intraflagellar transport motors cooperate to build sensory cilia on C. elegans neurons". Nat. Cell Biol. 6 (11): 1109–13. doi:10.1038/ncb1186. PMID 15489852. S2CID 22416282.
  12. ^ Dishinger JF, Kee HL, Jenkins PM, Fan S, Hurd TW, Hammond JW, Truong YN, Margolis B, Martens JR, Verhey KJ (July 2010). "Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-beta2 and RanGTP". Nat. Cell Biol. 12 (7): 703–10. doi:10.1038/ncb2073. PMC 2896429. PMID 20526328.

Further reading

  • Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (February 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
  • Macho B, Brancorsini S, Fimia GM, Setou M, Hirokawa N, Sassone-Corsi P (December 2002). "CREM-dependent transcription in male germ cells controlled by a kinesin". Science. 298 (5602): 2388–90. Bibcode:2002Sci...298.2388M. doi:10.1126/science.1077265. PMID 12493914. S2CID 42448155.
  • Guillaud L, Setou M, Hirokawa N (January 2003). "KIF17 dynamics and regulation of NR2B trafficking in hippocampal neurons". J. Neurosci. 23 (1): 131–40. doi:10.1523/JNEUROSCI.23-01-00131.2003. PMC 6742138. PMID 12514209.
  • Chennathukuzhi V, Morales CR, El-Alfy M, Hecht NB (December 2003). "The kinesin KIF17b and RNA-binding protein TB-RBP transport specific cAMP-responsive element modulator-regulated mRNAs in male germ cells". Proc. Natl. Acad. Sci. U.S.A. 100 (26): 15566–71. Bibcode:2003PNAS..10015566C. doi:10.1073/pnas.2536695100. PMC 307608. PMID 14673085.
  • Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.


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