ENTPD6

Protein-coding gene in the species Homo sapiens
ENTPD6
Identifiers
AliasesENTPD6, CD39L2, IL-6SAG, IL6ST2, NTPDase-6, dJ738P15.3, ectonucleoside triphosphate diphosphohydrolase 6 (putative), ectonucleoside triphosphate diphosphohydrolase 6
External IDsOMIM: 603160; MGI: 1202295; HomoloGene: 68170; GeneCards: ENTPD6; OMA:ENTPD6 - orthologs
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for ENTPD6
Genomic location for ENTPD6
Band20p11.21Start25,195,693 bp[1]
End25,228,075 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for ENTPD6
Genomic location for ENTPD6
Band2|2 G3Start150,749,042 bp[2]
End150,771,675 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • nucleus accumbens

  • middle frontal gyrus

  • anterior pituitary

  • caudate nucleus

  • prefrontal cortex

  • Brodmann area 10

  • right adrenal gland

  • Brodmann area 9

  • cingulate gyrus

  • minor salivary glands
Top expressed in
  • spermatocyte

  • spermatid

  • seminiferous tubule

  • dorsomedial hypothalamic nucleus

  • subiculum

  • paraventricular nucleus of hypothalamus

  • ventromedial nucleus

  • lateral hypothalamus

  • arcuate nucleus

  • seminal vesicula
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • nucleoside-triphosphatase activity
  • guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity
  • uridine-diphosphatase activity
  • hydrolase activity
  • nucleoside-diphosphatase activity
Cellular component
  • integral component of membrane
  • cell surface
  • Golgi membrane
  • plasma membrane
  • membrane
  • extracellular region
  • extracellular space
  • Golgi apparatus
Biological process
  • response to calcium ion
  • response to magnesium ion
  • nucleobase-containing small molecule catabolic process
  • metabolism
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

955

12497

Ensembl

ENSG00000197586

ENSMUSG00000033068

UniProt

O75354
Q5QPI7

Q3U0P5

RefSeq (mRNA)
NM_001114089
NM_001247
NM_001317941
NM_001322378
NM_001322379

NM_001322380
NM_001322381
NM_001322382
NM_001322383
NM_001322384
NM_001322385
NM_001322386
NM_001322387
NM_001322388
NM_001322389
NM_001322390
NM_001322391
NM_001322392
NM_001322393
NM_001322394
NM_001322395
NM_001322396
NM_001322397
NM_001322398

NM_172117
NM_001355068

RefSeq (protein)
NP_001107561
NP_001238
NP_001304870
NP_001309307
NP_001309308

NP_001309309
NP_001309310
NP_001309311
NP_001309312
NP_001309313
NP_001309314
NP_001309315
NP_001309316
NP_001309317
NP_001309318
NP_001309319
NP_001309320
NP_001309321
NP_001309322
NP_001309323
NP_001309324
NP_001309325
NP_001309326
NP_001309327

NP_742115
NP_001341997
NP_001357558
NP_001357559
NP_001357560

Location (UCSC)Chr 20: 25.2 – 25.23 MbChr 2: 150.75 – 150.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ectonucleoside triphosphate diphosphohydrolase 6 is an enzyme that in humans is encoded by the ENTPD6 gene.[5][6]

Function

ENTPD6 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD6 contains 4 apyrase-conserved regions, which is characteristic of NTPases.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000197586 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033068 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chadwick BP, Frischauf AM (Jun 1998). "The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster". Genomics. 50 (3): 357–67. doi:10.1006/geno.1998.5317. PMID 9676430.
  6. ^ a b "Entrez Gene: ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative function)".

Further reading

  • Chadwick BP, Frischauf AM (Sep 1997). "Cloning and mapping of a human and mouse gene with homology to ecto-ATPase genes". Mammalian Genome. 8 (9): 668–72. doi:10.1007/s003359900534. PMID 9271669. S2CID 42644202.
  • Hicks-Berger CA, Chadwick BP, Frischauf AM, Kirley TL (Nov 2000). "Expression and characterization of soluble and membrane-bound human nucleoside triphosphate diphosphohydrolase 6 (CD39L2)". The Journal of Biological Chemistry. 275 (44): 34041–5. doi:10.1074/jbc.M004723200. PMID 10948193.
  • Yeung G, Mulero JJ, McGowan DW, Bajwa SS, Ford JE (Oct 2000). "CD39L2, a gene encoding a human nucleoside diphosphatase, predominantly expressed in the heart". Biochemistry. 39 (42): 12916–23. doi:10.1021/bi000959z. PMID 11041856.
  • Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Ivanenkov VV, Murphy-Piedmonte DM, Kirley TL (Oct 2003). "Bacterial expression, characterization, and disulfide bond determination of soluble human NTPDase6 (CD39L2) nucleotidase: implications for structure and function". Biochemistry. 42 (40): 11726–35. doi:10.1021/bi035137r. PMID 14529283.
  • Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
  • Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.


  • v
  • t
  • e