EDEM2 |
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Identifiers |
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Aliases | EDEM2, C20orf31, C20orf49, bA4204.1, ER degradation enhancing alpha-mannosidase like protein 2 |
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External IDs | OMIM: 610302; MGI: 1915540; HomoloGene: 10075; GeneCards: EDEM2; OMA:EDEM2 - orthologs |
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Gene location (Human) |
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![Chromosome 20 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/f/ff/Ideogram_human_chromosome_20.svg/300px-Ideogram_human_chromosome_20.svg.png) | Chr. | Chromosome 20 (human)[1] |
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| Band | 20q11.22 | Start | 35,115,364 bp[1] |
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End | 35,147,336 bp[1] |
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Gene location (Mouse) |
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![Chromosome 2 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/b/bb/Ideogram_house_mouse_chromosome_2.svg/260px-Ideogram_house_mouse_chromosome_2.svg.png) | Chr. | Chromosome 2 (mouse)[2] |
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| Band | 2|2 H1 | Start | 155,543,597 bp[2] |
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End | 155,571,395 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - granulocyte
- monocyte
- right lobe of liver
- islet of Langerhans
- right adrenal gland
- body of pancreas
- left adrenal gland
- mucosa of transverse colon
- decidua
- right adrenal cortex
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| Top expressed in | - lacrimal gland
- decidua
- islet of Langerhans
- salivary gland
- parotid gland
- crypt of lieberkuhn of small intestine
- pyloric antrum
- seminal vesicula
- epithelium of stomach
- submandibular gland
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| More reference expression data |
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/c/ce/PBB_GE_EDEM2_218282_at_fs.png/250px-PBB_GE_EDEM2_218282_at_fs.png) | More reference expression data |
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Gene ontology |
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Molecular function | - calcium ion binding
- mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
- catalytic activity
| Cellular component | - endoplasmic reticulum lumen
- endoplasmic reticulum
- membrane
- endoplasmic reticulum quality control compartment
| Biological process | - endoplasmic reticulum unfolded protein response
- mannose trimming involved in glycoprotein ERAD pathway
- N-glycan processing
- positive regulation of retrograde protein transport, ER to cytosol
- response to unfolded protein
- ubiquitin-dependent glycoprotein ERAD pathway
- trimming of terminal mannose on B branch
- trimming of terminal mannose on C branch
- trimming of first mannose on A branch
- trimming of second mannose on A branch
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 20: 35.12 – 35.15 Mb | Chr 2: 155.54 – 155.57 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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