EDEM2

Protein-coding gene in the species Homo sapiens
EDEM2
Identifiers
AliasesEDEM2, C20orf31, C20orf49, bA4204.1, ER degradation enhancing alpha-mannosidase like protein 2
External IDsOMIM: 610302; MGI: 1915540; HomoloGene: 10075; GeneCards: EDEM2; OMA:EDEM2 - orthologs
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for EDEM2
Genomic location for EDEM2
Band20q11.22Start35,115,364 bp[1]
End35,147,336 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for EDEM2
Genomic location for EDEM2
Band2|2 H1Start155,543,597 bp[2]
End155,571,395 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • monocyte

  • right lobe of liver

  • islet of Langerhans

  • right adrenal gland

  • body of pancreas

  • left adrenal gland

  • mucosa of transverse colon

  • decidua

  • right adrenal cortex
Top expressed in
  • lacrimal gland

  • decidua

  • islet of Langerhans

  • salivary gland

  • parotid gland

  • crypt of lieberkuhn of small intestine

  • pyloric antrum

  • seminal vesicula

  • epithelium of stomach

  • submandibular gland
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • calcium ion binding
  • mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
  • catalytic activity
Cellular component
  • endoplasmic reticulum lumen
  • endoplasmic reticulum
  • membrane
  • endoplasmic reticulum quality control compartment
Biological process
  • endoplasmic reticulum unfolded protein response
  • mannose trimming involved in glycoprotein ERAD pathway
  • N-glycan processing
  • positive regulation of retrograde protein transport, ER to cytosol
  • response to unfolded protein
  • ubiquitin-dependent glycoprotein ERAD pathway
  • trimming of terminal mannose on B branch
  • trimming of terminal mannose on C branch
  • trimming of first mannose on A branch
  • trimming of second mannose on A branch
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55741

108687

Ensembl

ENSG00000088298

ENSMUSG00000038312

UniProt

Q9BV94

Q8BJT9

RefSeq (mRNA)

NM_001145025
NM_018217

NM_145537

RefSeq (protein)

NP_001138497
NP_060687

NP_663512

Location (UCSC)Chr 20: 35.12 – 35.15 MbChr 2: 155.54 – 155.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ER degradation-enhancing alpha-mannosidase-like 2 is an enzyme that in humans is encoded by the EDEM2 gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000088298 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038312 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mast SW, Diekman K, Karaveg K, Davis A, Sifers RN, Moremen KW (Mar 2005). "Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins". Glycobiology. 15 (4): 421–36. doi:10.1093/glycob/cwi014. PMID 15537790.
  6. ^ Olivari S, Galli C, Alanen H, Ruddock L, Molinari M (Jan 2005). "A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation". J Biol Chem. 280 (4): 2424–8. doi:10.1074/jbc.C400534200. PMID 15579471.
  7. ^ "Entrez Gene: EDEM2 ER degradation enhancer, mannosidase alpha-like 2".

Further reading

  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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