DYNC1LI2

Protein-coding gene in the species Homo sapiens
DYNC1LI2
Identifiers
AliasesDYNC1LI2, DNCLI2, LIC2, dynein cytoplasmic 1 light intermediate chain 2
External IDsOMIM: 611406; MGI: 107738; HomoloGene: 4474; GeneCards: DYNC1LI2; OMA:DYNC1LI2 - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for DYNC1LI2
Genomic location for DYNC1LI2
Band16q22.1Start66,720,893 bp[1]
End66,751,609 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for DYNC1LI2
Genomic location for DYNC1LI2
Band8 D3|8 53.04 cMStart105,144,312 bp[2]
End105,169,679 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • endothelial cell

  • inferior ganglion of vagus nerve

  • pars reticulata

  • subthalamic nucleus

  • external globus pallidus

  • internal globus pallidus

  • Pars compacta

  • Brodmann area 23

  • superior vestibular nucleus

  • pons
Top expressed in
  • central gray substance of midbrain

  • hand

  • neural layer of retina

  • globus pallidus

  • superior frontal gyrus

  • cerebellar cortex

  • deep cerebellar nuclei

  • inferior colliculus

  • medial geniculate nucleus

  • pontine nuclei
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • microtubule motor activity
  • nucleotide binding
  • cytoskeletal motor activity
  • ATP binding
  • dynein heavy chain binding
Cellular component
  • cytoplasm
  • cytosol
  • membrane
  • dynein complex
  • microtubule
  • cytoskeleton
  • cytoplasmic dynein complex
  • kinetochore
  • lysosome
  • late endosome
  • centrosome
Biological process
  • antigen processing and presentation of exogenous peptide antigen via MHC class II
  • centrosome localization
  • endoplasmic reticulum to Golgi vesicle-mediated transport
  • microtubule cytoskeleton organization
  • microtubule-based movement
  • sister chromatid cohesion
  • transport
  • protein homooligomerization
  • cellular response to nerve growth factor stimulus
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1783

234663

Ensembl

ENSG00000135720

ENSMUSG00000035770

UniProt

O43237

Q6PDL0

RefSeq (mRNA)

NM_001286157
NM_006141
NM_001323955

NM_001013380

RefSeq (protein)

NP_001273086
NP_001310884
NP_006132
NP_006132.1

NP_001013398

Location (UCSC)Chr 16: 66.72 – 66.75 MbChr 8: 105.14 – 105.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cytoplasmic dynein 1 light intermediate chain 2 is a protein that in humans is encoded by the DYNC1LI2 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135720 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035770 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (Nov 2005). "Cytoplasmic dynein nomenclature". J Cell Biol. 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC 2171247. PMID 16260502.
  6. ^ "Entrez Gene: DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2".

Further reading

  • Hughes SM, Vaughan KT, Herskovits JS, Vallee RB (1995). "Molecular analysis of a cytoplasmic dynein light intermediate chain reveals homology to a family of ATPases". J. Cell Sci. 108 (1): 17–24. doi:10.1242/jcs.108.1.17. PMID 7738094.
  • Chagnon P, Michaud J, Mitchell G, et al. (2003). "A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis". Am. J. Hum. Genet. 71 (6): 1443–9. doi:10.1086/344580. PMC 378590. PMID 12417987.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.


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