DYNC1LI1

Protein-coding gene in the species Homo sapiens
DYNC1LI1
Identifiers
AliasesDYNC1LI1, DNCLI1, LIC1, dynein cytoplasmic 1 light intermediate chain 1, DLC-A
External IDsOMIM: 615890; MGI: 2135610; HomoloGene: 9403; GeneCards: DYNC1LI1; OMA:DYNC1LI1 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for DYNC1LI1
Genomic location for DYNC1LI1
Band3p22.3Start32,525,974 bp[1]
End32,570,858 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for DYNC1LI1
Genomic location for DYNC1LI1
Band9|9 F3Start114,517,858 bp[2]
End114,553,370 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • monocyte

  • right ventricle

  • ganglionic eminence

  • gonad

  • lateral nuclear group of thalamus

  • pons

  • testicle

  • gastrocnemius muscle

  • ventricular zone

  • biceps brachii
Top expressed in
  • neural layer of retina

  • granulocyte

  • interventricular septum

  • gastrula

  • primary visual cortex

  • right kidney

  • muscle of thigh

  • superior frontal gyrus

  • ankle

  • decidua
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • microtubule motor activity
  • nucleotide binding
  • GDP binding
  • dynein heavy chain binding
  • GTP binding
  • protein binding
  • cytoskeletal motor activity
  • ATP binding
  • RNA binding
Cellular component
  • centrosome
  • spindle pole
  • membrane
  • chromosome
  • cytoplasmic dynein complex
  • dynein complex
  • microtubule
  • chromosome, centromeric region
  • cytoskeleton
  • kinetochore
  • cytoplasm
  • cytosol
  • plasma membrane
  • secretory granule membrane
  • ficolin-1-rich granule membrane
Biological process
  • positive regulation of mitotic cell cycle spindle assembly checkpoint
  • cell division
  • cell cycle
  • viral process
  • microtubule cytoskeleton organization
  • endoplasmic reticulum to Golgi vesicle-mediated transport
  • microtubule-based movement
  • antigen processing and presentation of exogenous peptide antigen via MHC class II
  • neutrophil degranulation
  • sister chromatid cohesion
  • transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51143

235661

Ensembl

ENSG00000144635

ENSMUSG00000032435

UniProt

Q9Y6G9

Q8R1Q8

RefSeq (mRNA)

NM_016141
NM_001329135

NM_146229

RefSeq (protein)

NP_001316064
NP_057225

NP_666341

Location (UCSC)Chr 3: 32.53 – 32.57 MbChr 9: 114.52 – 114.55 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cytoplasmic dynein 1 light intermediate chain 1 is a protein that in humans is encoded by the DYNC1LI1 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000144635 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032435 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (Nov 2005). "Cytoplasmic dynein nomenclature". J Cell Biol. 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC 2171247. PMID 16260502.
  6. ^ "Entrez Gene: DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Tynan SH, Purohit A, Doxsey SJ, Vallee RB (2000). "Light intermediate chain 1 defines a functional subfraction of cytoplasmic dynein which binds to pericentrin". J. Biol. Chem. 275 (42): 32763–8. doi:10.1074/jbc.M001536200. PMID 10893222.
  • Bielli A, Thörnqvist PO, Hendrick AG, et al. (2001). "The small GTPase Rab4A interacts with the central region of cytoplasmic dynein light intermediate chain-1". Biochem. Biophys. Res. Commun. 281 (5): 1141–53. doi:10.1006/bbrc.2001.4468. PMID 11243854.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
  • Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.


  • v
  • t
  • e