DYNC1I2

Protein-coding gene in the species Homo sapiens
DYNC1I2
Identifiers
AliasesDYNC1I2, DNCI2, IC2, DIC74, dynein cytoplasmic 1 intermediate chain 2, NEDMIBA
External IDsOMIM: 603331; MGI: 107750; HomoloGene: 133934; GeneCards: DYNC1I2; OMA:DYNC1I2 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for DYNC1I2
Genomic location for DYNC1I2
Band2q31.1Start171,687,409 bp[1]
End171,750,158 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for DYNC1I2
Genomic location for DYNC1I2
Band2 C2|2 42.38 cMStart71,042,050 bp[2]
End71,093,647 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • ganglionic eminence

  • C1 segment

  • ventricular zone

  • sural nerve

  • smooth muscle tissue

  • islet of Langerhans

  • popliteal artery

  • tibial arteries

  • Descending thoracic aorta
Top expressed in
  • genital tubercle

  • ganglionic eminence

  • spermatocyte

  • barrel cortex

  • medial ganglionic eminence

  • fossa

  • superior cervical ganglion

  • condyle

  • median eminence

  • zygote
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • microtubule motor activity
  • protein binding
  • cytoskeletal motor activity
  • plus-end-directed microtubule motor activity
  • dynein light chain binding
  • dynein heavy chain binding
Cellular component
  • vesicle
  • cytosol
  • centrosome
  • dynein complex
  • cytoskeleton
  • cytoplasm
  • microtubule
  • cytoplasmic dynein complex
Biological process
  • antigen processing and presentation of exogenous peptide antigen via MHC class II
  • endoplasmic reticulum to Golgi vesicle-mediated transport
  • G2/M transition of mitotic cell cycle
  • viral process
  • microtubule-based movement
  • ciliary basal body-plasma membrane docking
  • transport along microtubule
  • regulation of G2/M transition of mitotic cell cycle
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1781

13427

Ensembl

ENSG00000077380

ENSMUSG00000027012

UniProt

Q13409

O88487

RefSeq (mRNA)
NM_001271785
NM_001271786
NM_001271787
NM_001271788
NM_001271789

NM_001271790
NM_001378
NM_001320882
NM_001320883
NM_001320884
NM_001378455
NM_001378456

NM_001198872
NM_001198873
NM_001198874
NM_001198875
NM_001198876

NM_001198877
NM_001198878
NM_010064
NM_001347173

RefSeq (protein)
NP_001258714
NP_001258715
NP_001258716
NP_001258717
NP_001258718

NP_001258719
NP_001307811
NP_001307812
NP_001307813
NP_001369
NP_001365384
NP_001365385

NP_001185801
NP_001185802
NP_001185803
NP_001185804
NP_001185805

NP_001185806
NP_001185807
NP_001334102
NP_034194

Location (UCSC)Chr 2: 171.69 – 171.75 MbChr 2: 71.04 – 71.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cytoplasmic dynein 1 intermediate chain 2 is a protein that in humans is encoded by the DYNC1I2 gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000077380 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027012 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Crackower MA, Sinasac DS, Xia J, Motoyama J, Prochazka M, Rommens JM, Scherer SW, Tsui LC (May 1999). "Cloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human". Genomics. 55 (3): 257–67. doi:10.1006/geno.1998.5665. PMID 10049579.
  6. ^ Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (Nov 2005). "Cytoplasmic dynein nomenclature". J Cell Biol. 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC 2171247. PMID 16260502.
  7. ^ "Entrez Gene: DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Vaughan KT, Vallee RB (1996). "Cytoplasmic dynein binds dynactin through a direct interaction between the intermediate chains and p150Glued". J. Cell Biol. 131 (6 Pt 1): 1507–16. doi:10.1083/jcb.131.6.1507. PMC 2120689. PMID 8522607.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Davies TH, Ning YM, Sánchez ER (2002). "A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins". J. Biol. Chem. 277 (7): 4597–600. doi:10.1074/jbc.C100531200. PMID 11751894.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Fortna A, Kim Y, MacLaren E, et al. (2006). "Lineage-Specific Gene Duplication and Loss in Human and Great Ape Evolution". PLOS Biol. 2 (7): E207. doi:10.1371/journal.pbio.0020207. PMC 449870. PMID 15252450.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • v
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  • 2pg1: Structural analysis of a cytoplasmic dynein Light Chain-Intermediate Chain complex
    2pg1: Structural analysis of a cytoplasmic dynein Light Chain-Intermediate Chain complex


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