Clevudine

Chemical compound
  • J05AF12 (WHO) [1]
Identifiers
  • 1-[(2S,3R,4S,5S)-3-fluoro-4-hydroxy-5- (hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine- 2,4-dione
CAS Number
  • 163252-36-6 checkY
  • active moiety: 69256-17-3 checkY
PubChem CID
  • 73115
ChemSpider
  • 65894 ☒N
UNII
  • IN51MVP5F1
  • active moiety: 37F7D05ANB checkY
KEGG
  • D03537 checkY
ChEMBL
  • ChEMBL458875 ☒N
CompTox Dashboard (EPA)
  • DTXSID2057659 Edit this at Wikidata
Chemical and physical dataFormulaC10H13FN2O5Molar mass260.221 g·mol−13D model (JSmol)
  • Interactive image
  • O=C/1NC(=O)N(\C=C\1C)[C@H]2O[C@H]([C@H](O)[C@H]2F)CO
InChI
  • InChI=1S/C10H13FN2O5/c1-4-2-13(10(17)12-8(4)16)9-6(11)7(15)5(3-14)18-9/h2,5-7,9,14-15H,3H2,1H3,(H,12,16,17)/t5-,6+,7-,9-/m0/s1 ☒N
  • Key:GBBJCSTXCAQSSJ-XQXXSGGOSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Clevudine (INN) is an antiviral drug for the treatment of hepatitis B (HBV). It is already approved for HBV in South Korea and the Philippines. It is marketed by Bukwang Pharmaceuticals in South Korea under the tradenames Levovir and Revovir.

Researchers in South Korea are testing clevudine at lower doses in combination with adefovir for continued use.[2]

It is a nucleoside analog.[3]

References

  1. ^ WHO International Working Group for Drug Statistics Methodology (August 27, 2008). "ATC/DDD Classification (FINAL): New ATC 5th level codes". WHO Collaborating Centre for Drug Statistics Methodology. Archived from the original on 2008-05-06. Retrieved 2008-09-05.
  2. ^ Tak WY, Yang JM, Kim BI, Baik SK, Cheon GJ, Byun KS, Kim DY, Yoo BC, et al. (May 2014). "A randomized, open-label study comparing low-dose clevudine plus adefovir combination therapy with clevudine monotherapy in naïve chronic hepatitis B patients". Hepatology International. 8 (3): 375–381. doi:10.1007/s12072-014-9537-5. PMC 4116600. PMID 25101150.
  3. ^ Lee HS, Chung YH, Lee K, et al. (May 2006). "A 12-week clevudine therapy showed potent and durable antiviral activity in HBeAg-positive chronic hepatitis B". Hepatology. 43 (5): 982–8. doi:10.1002/hep.21166. PMID 16628625.
  • v
  • t
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DNA virus antivirals (primarily J05, also S01AD and D06BB)
Baltimore I
Herpesvirus
DNA-synthesis
inhibitor
TK activated
Purine analogue
Pyrimidine analogue
Not TK activated
Other
HPV/MC
Vaccinia
Poxviridae
Hepatitis B (VII)Multiple/general
Nucleic acid inhibitors
Interferon
Multiple/unknown


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