CSDC2

Protein-coding gene in the species Homo sapiens
CSDC2
Identifiers
AliasesCSDC2, PIPPIN, dJ347H13.2, cold shock domain containing C2
External IDsOMIM: 617689; MGI: 2146027; HomoloGene: 8701; GeneCards: CSDC2; OMA:CSDC2 - orthologs
Gene location (Human)
Chromosome 22 (human)
Chr.Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for CSDC2
Genomic location for CSDC2
Band22q13.2Start41,561,010 bp[1]
End41,577,741 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for CSDC2
Genomic location for CSDC2
Band15|15 E1Start81,820,960 bp[2]
End81,835,142 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • apex of heart

  • right auricle

  • left ventricle

  • right coronary artery

  • left adrenal cortex

  • right adrenal gland

  • left ovary

  • right adrenal cortex

  • right ovary

  • popliteal artery
Top expressed in
  • pontine nuclei

  • medial geniculate nucleus

  • gastrula

  • medial vestibular nucleus

  • medial dorsal nucleus

  • dorsal tegmental nucleus

  • inferior colliculus

  • motor neuron

  • cerebellar cortex

  • cerebellar vermis
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • protein binding
  • RNA binding
  • nucleic acid binding
  • mRNA 3'-UTR binding
  • transcription factor binding
Cellular component
  • nucleus
  • cytoplasm
Biological process
  • mRNA processing
  • regulation of transcription, DNA-templated
  • regulation of mRNA stability
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

27254

105859

Ensembl

ENSG00000172346

ENSMUSG00000042109

UniProt

Q9Y534

Q91YQ3

RefSeq (mRNA)

NM_014460

NM_145473

RefSeq (protein)

NP_055275

NP_663448

Location (UCSC)Chr 22: 41.56 – 41.58 MbChr 15: 81.82 – 81.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cold shock domain-containing protein C2 is a protein that in humans is encoded by the CSDC2 gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000172346 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042109 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Castiglia D, Scaturro M, Nastasi T, Cestelli A, Di Liegro I (Mar 1996). "PIPPin, a putative RNA-binding protein specifically expressed in the rat brain". Biochem Biophys Res Commun. 218 (1): 390–4. doi:10.1006/bbrc.1996.0068. PMID 8573167.
  6. ^ Raimondi L, D'Asaro M, Proia P, Nastasi T, Di Liegro I (May 2003). "RNA-binding ability of PIPPin requires the entire protein". J Cell Mol Med. 7 (1): 35–42. doi:10.1111/j.1582-4934.2003.tb00200.x. PMC 6740078. PMID 12767259.
  7. ^ "Entrez Gene: CSDC2 cold shock domain containing C2, RNA binding".

External links

Further reading

  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Nastasi T, Scaturro M, Bellafiore M, et al. (1999). "PIPPin is a brain-specific protein that contains a cold-shock domain and binds specifically to H1 degrees and H3.3 mRNAs". J. Biol. Chem. 274 (34): 24087–93. doi:10.1074/jbc.274.34.24087. PMID 10446180.
  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
  • Nastasi T, Muzi P, Beccari S, et al. (2001). "Specific neurons of brain cortex and cerebellum are PIPPin positive". NeuroReport. 11 (10): 2233–6. doi:10.1097/00001756-200007140-00034. PMID 10923677. S2CID 28313328.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Schäfer C, Steffen H, Krzykowski KJ, et al. (2003). "CRHSP-24 phosphorylation is regulated by multiple signaling pathways in pancreatic acinar cells". Am. J. Physiol. Gastrointest. Liver Physiol. 285 (4): G726–34. doi:10.1152/ajpgi.00111.2003. PMID 12801884.
  • Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.


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