Mammalian protein found in Homo sapiens
CCL3 |
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Available structures |
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PDB | Human UniProt search: PDBe RCSB |
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List of PDB id codes |
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1B50, 1B53, 2X69, 2X6G, 3FPU, 3H44, 3KBX, 4RA8, 4ZKB, 5D65, 5COR |
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Identifiers |
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Aliases | CCL3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3, C-C motif chemokine ligand 3 |
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External IDs | OMIM: 182283 HomoloGene: 88430 GeneCards: CCL3 |
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Gene location (Human) |
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| Chr. | Chromosome 17 (human)[1] |
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| Band | 17q12 | Start | 36,088,256 bp[1] |
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End | 36,090,169 bp[1] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - bone marrow
- spleen
- monocyte
- bone marrow cells
- gallbladder
- placenta
- lymph node
- appendix
- blood
- upper lobe of left lung
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BioGPS | | More reference expression data |
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Gene ontology |
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Molecular function | - protein kinase activity
- cytokine activity
- CCR5 chemokine receptor binding
- chemokine activity
- CCR1 chemokine receptor binding
- kinase activity
- phospholipase activator activity
- calcium-dependent protein kinase C activity
- protein binding
- identical protein binding
- chemoattractant activity
- CCR chemokine receptor binding
| Cellular component | - cytoplasm
- cytosol
- intracellular anatomical structure
- extracellular region
- extracellular space
| Biological process | - G protein-coupled receptor signaling pathway
- signaling
- negative regulation of bone mineralization
- positive regulation of protein kinase B signaling
- release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
- response to cholesterol
- positive regulation of calcium-mediated signaling
- regulation of sensory perception of pain
- protein kinase B signaling
- monocyte chemotaxis
- negative regulation of osteoclast differentiation
- astrocyte cell migration
- positive regulation of cell migration
- positive regulation of natural killer cell chemotaxis
- chemokine-mediated signaling pathway
- T cell chemotaxis
- cell-cell signaling
- cellular response to tumor necrosis factor
- eosinophil chemotaxis
- cellular response to organic cyclic compound
- cellular calcium ion homeostasis
- negative regulation of gene expression
- neutrophil chemotaxis
- cell activation
- MAPK cascade
- chemotaxis
- positive regulation of GTPase activity
- positive regulation of neuron apoptotic process
- positive regulation of calcium ion import
- macrophage chemotaxis
- positive regulation of gene expression
- cytoskeleton organization
- osteoblast differentiation
- cellular response to interleukin-1
- immune response
- positive regulation of ERK1 and ERK2 cascade
- regulation of cell shape
- positive regulation of tumor necrosis factor production
- cellular response to interferon-gamma
- lymphocyte chemotaxis
- inflammatory response
- granulocyte chemotaxis
- response to toxic substance
- eosinophil degranulation
- lipopolysaccharide-mediated signaling pathway
- calcium ion transport
- calcium-mediated signaling
- exocytosis
- positive regulation of calcium ion transport
- positive chemotaxis
- positive regulation of inflammatory response
- regulation of signaling receptor activity
- cytokine-mediated signaling pathway
- regulation of behavior
- positive regulation of microglial cell activation
- positive regulation of microglial cell migration
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | |
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ENSG00000278567 ENSG00000277632 ENSG00000274221 |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 17: 36.09 – 36.09 Mb | n/a |
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PubMed search | [2] | n/a |
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Wikidata |
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Chemokine (C-C motif) ligand 3 (CCL3) also known as macrophage inflammatory protein 1-alpha (MIP-1-alpha) is a protein that in humans is encoded by the CCL3 gene.[3]
Function
CCL3 is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes[4] through binding to the receptors CCR1, CCR4 and CCR5.[3]
Sherry et al. (1988) demonstrated 2 protein components of MIP1, called by them alpha (CCL3, this protein) and beta (CCL4).[5][3]
CCL3 produces a monophasic fever of rapid onset whose magnitude is equal to or greater than that of fevers produced with either recombinant human tumor necrosis factor or recombinant human interleukin-1. However, in contrast to these two endogenous pyrogens, the fever induced by MIP-1 is not inhibited by the cyclooxygenase inhibitor ibuprofen and CCL3 may participate in the febrile response that is not mediated through prostaglandin synthesis and clinically cannot be ablated by cyclooxygenase.[6]
Interactions
CCL3 has been shown to interact with CCL4.[7] Attracts macrophages, monocytes and neutrophils.
See also
References
- ^ a b c ENSG00000277632, ENSG00000274221 GRCh38: Ensembl release 89: ENSG00000278567, ENSG00000277632, ENSG00000274221 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b c "Entrez Gene: CCL3 chemokine (C-C motif) ligand 3".
- ^ Wolpe SD, Davatelis G, Sherry B, Beutler B, Hesse DG, Nguyen HT, Moldawer LL, Nathan CF, Lowry SF, Cerami A (1988). "Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties". The Journal of Experimental Medicine. 167 (2): 570–81. doi:10.1084/jem.167.2.570. PMC 2188834. PMID 3279154.
- ^ Sherry B, Tekamp-Olson P, Gallegos C, Bauer D, Davatelis G, Wolpe SD, Masiarz F, Coit D, Cerami A (1988). "Resolution of the two components of macrophage inflammatory protein 1, and cloning and characterization of one of those components, macrophage inflammatory protein 1 beta". The Journal of Experimental Medicine. 168 (6): 2251–9. doi:10.1084/jem.168.6.2251. PMC 2189160. PMID 3058856.
- ^ Davatelis G, Wolpe SD, Sherry B, Dayer JM, Chicheportiche R, Cerami A (1989). "Macrophage inflammatory protein-1: a prostaglandin-independent endogenous pyrogen". Science. 243 (4894 Pt 1): 1066–8. Bibcode:1989Sci...243.1066D. doi:10.1126/science.2646711. PMID 2646711.
- ^ Guan E, Wang J, Norcross MA (Apr 2001). "Identification of human macrophage inflammatory proteins 1alpha and 1beta as a native secreted heterodimer". The Journal of Biological Chemistry. 276 (15): 12404–9. doi:10.1074/jbc.M006327200. PMID 11278300.
External links
Further reading
- Menten P, Wuyts A, Van Damme J (Dec 2002). "Macrophage inflammatory protein-1". Cytokine & Growth Factor Reviews. 13 (6): 455–81. doi:10.1016/S1359-6101(02)00045-X. PMID 12401480.
- Muthumani K, Desai BM, Hwang DS, Choo AY, Laddy DJ, Thieu KP, Rao RG, Weiner DB (Apr 2004). "HIV-1 Vpr and anti-inflammatory activity". DNA and Cell Biology. 23 (4): 239–47. doi:10.1089/104454904773819824. PMID 15142381.
- Joseph AM, Kumar M, Mitra D (Jan 2005). "Nef: "necessary and enforcing factor" in HIV infection". Current HIV Research. 3 (1): 87–94. doi:10.2174/1570162052773013. PMID 15638726.
- Zhao RY, Elder RT (Mar 2005). "Viral infections and cell cycle G2/M regulation". Cell Research. 15 (3): 143–9. doi:10.1038/sj.cr.7290279. PMID 15780175.
- Zhao RY, Bukrinsky M, Elder RT (Apr 2005). "HIV-1 viral protein R (Vpr) & host cellular responses". The Indian Journal of Medical Research. 121 (4): 270–86. PMID 15817944.
- Li L, Li HS, Pauza CD, Bukrinsky M, Zhao RY (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions". Cell Research. 15 (11–12): 923–34. doi:10.1038/sj.cr.7290370. PMID 16354571.
PDB gallery
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1b50: NMR STRUCTURE OF HUMAN MIP-1A D26A, 10 STRUCTURES -
1b53: NMR STRUCTURE OF HUMAN MIP-1A D26A, MINIMIZED AVERAGE STRUCTURE |
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