Biotin—CoA ligase
Biotin—CoA ligase | |||||||||
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Identifiers | |||||||||
EC no. | 6.2.1.11 | ||||||||
CAS no. | 37318-60-8 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a biotin—CoA ligase (EC 6.2.1.11) is an enzyme that catalyzes the chemical reaction
- ATP + biotin + CoA AMP + diphosphate + biotinyl-CoA
The 3 substrates of this enzyme are ATP, biotin, and CoA, whereas its 3 products are AMP, diphosphate, and biotinyl-CoA.
This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is biotin:CoA ligase (AMP-forming). Other names in common use include biotinyl-CoA synthetase, biotin CoA synthetase, and biotinyl coenzyme A synthetase. This enzyme participates in biotin metabolism.
References
- CHRISTNER JE, SCHLESINGER MJ, COON MJ (1964). "ENZYMATIC ACTIVATION OF BIOTIN. BIOTINYL ADENYLATE FORMATION". J. Biol. Chem. 239: 3997–4005. PMID 14257635.
- v
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- Aminoacyl tRNA synthetase
- Alanine
- Arginine
- Asparagine
- Aspartate
- Cysteine
- D-alanine—poly(phosphoribitol) ligase
- Glutamate
- Glutamine
- Glycine
- Histidine
- Isoleucine
- Leucine
- Lysine
- Methionine
- Phenylalanine
- Proline
- Serine
- Threonine
- Tryptophan
- Tyrosine
- Valine
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