ARL6IP1

Protein-coding gene in the species Homo sapiens
ARL6IP1
Identifiers
AliasesARL6IP1, AIP1, ARL6IP, ARMER, SPG61, ADP ribosylation factor like GTPase 6 interacting protein 1
External IDsOMIM: 607669; MGI: 1858943; HomoloGene: 41008; GeneCards: ARL6IP1; OMA:ARL6IP1 - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for ARL6IP1
Genomic location for ARL6IP1
Band16p12.3Start18,791,669 bp[1]
End18,801,572 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for ARL6IP1
Genomic location for ARL6IP1
Band7|7 F1Start117,718,114 bp[2]
End117,728,885 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • retinal pigment epithelium

  • ventricular zone

  • superior frontal gyrus

  • embryo

  • ganglionic eminence

  • postcentral gyrus

  • pons

  • Brodmann area 9

  • orbitofrontal cortex

  • prefrontal cortex
Top expressed in
  • retinal pigment epithelium

  • Epithelium of choroid plexus

  • spermatocyte

  • neural layer of retina

  • right kidney

  • yolk sac

  • choroid plexus of fourth ventricle

  • ciliary body

  • fetal liver hematopoietic progenitor cell

  • human kidney
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • identical protein binding
Cellular component
  • cytoplasm
  • cytosol
  • membrane
  • Sec61 translocon complex
  • endoplasmic reticulum
  • endomembrane system
  • endoplasmic reticulum membrane
  • integral component of endoplasmic reticulum membrane
  • integral component of membrane
Biological process
  • cotranslational protein targeting to membrane
  • endoplasmic reticulum tubular network formation
  • apoptotic process
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
  • endoplasmic reticulum tubular network membrane organization
  • negative regulation of apoptotic process
  • positive regulation of L-glutamate import across plasma membrane
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23204

54208

Ensembl

ENSG00000170540

ENSMUSG00000030654

UniProt

Q15041

Q9JKW0

RefSeq (mRNA)

NM_015161
NM_001313858

NM_019419

RefSeq (protein)

NP_001300787
NP_055976

NP_062292

Location (UCSC)Chr 16: 18.79 – 18.8 MbChr 7: 117.72 – 117.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ADP-ribosylation factor-like protein 6-interacting protein 1 is a protein that in humans is encoded by the ARL6IP1 gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170540 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030654 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1".

External links

Further reading

  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Lui HM, Chen J, Wang L, Naumovski L (2003). "ARMER, apoptotic regulator in the membrane of the endoplasmic reticulum, a novel inhibitor of apoptosis". Mol. Cancer Res. 1 (7): 508–18. PMID 12754298.
  • Pettersson M, Bessonova M, Gu HF, Groop LC, Jönsson JI (2000). "Characterization, chromosomal localization, and expression during hematopoietic differentiation of the gene encoding Arl6ip, ADP-ribosylation-like factor-6 interacting protein (ARL6)". Genomics. 68 (3): 351–4. doi:10.1006/geno.2000.6278. PMID 10995579.
  • Ingley E, Williams JH, Walker CE, Tsai S, Colley S, Sayer MS, Tilbrook PA, Sarna M, Beaumont JG, Klinken SP (1999). "A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit". FEBS Lett. 459 (1): 69–74. doi:10.1016/S0014-5793(99)01188-6. PMID 10508919. S2CID 30948975.
  • Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (1994). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.


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