ARFGAP3

Protein-coding gene in the species Homo sapiens
ARFGAP3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2CRW

Identifiers
AliasesARFGAP3, ARFGAP1, ADP ribosylation factor GTPase activating protein 3
External IDsOMIM: 612439; MGI: 1913501; HomoloGene: 134103; GeneCards: ARFGAP3; OMA:ARFGAP3 - orthologs
Gene location (Human)
Chromosome 22 (human)
Chr.Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for ARFGAP3
Genomic location for ARFGAP3
Band22q13.2Start42,796,502 bp[1]
End42,858,106 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for ARFGAP3
Genomic location for ARFGAP3
Band15|15 E1Start83,183,940 bp[2]
End83,234,448 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • jejunal mucosa

  • parotid gland

  • body of pancreas

  • Achilles tendon

  • tibia

  • left adrenal gland

  • corpus epididymis

  • islet of Langerhans

  • palpebral conjunctiva

  • seminal vesicula
Top expressed in
  • lacrimal gland

  • seminal vesicula

  • salivary gland

  • parotid gland

  • islet of Langerhans

  • submandibular gland

  • spermatocyte

  • duodenum

  • spermatid

  • large intestine
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • metal ion binding
  • GTPase activator activity
Cellular component
  • cytosol
  • Golgi membrane
  • Golgi apparatus
  • membrane
  • cytoplasm
  • endoplasmic reticulum-Golgi intermediate compartment
  • trans-Golgi network
  • COPI vesicle coat
Biological process
  • protein transport
  • endoplasmic reticulum to Golgi vesicle-mediated transport
  • intracellular protein transport
  • vesicle-mediated transport
  • protein secretion
  • retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
  • positive regulation of GTPase activity
  • transport
  • COPI coating of Golgi vesicle
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26286

66251

Ensembl

ENSG00000242247

ENSMUSG00000054277

UniProt

Q9NP61

Q9D8S3

RefSeq (mRNA)

NM_001142293
NM_014570

NM_025445
NM_001357756
NM_001357757

RefSeq (protein)

NP_001135765
NP_055385

NP_079721
NP_001344685
NP_001344686

Location (UCSC)Chr 22: 42.8 – 42.86 MbChr 15: 83.18 – 83.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ADP-ribosylation factor GTPase-activating protein 3 is a protein that in humans is encoded by the ARFGAP3 gene.[5][6][7]

The protein encoded by this gene is a GTPase-activating protein (GAP) which associates with the Golgi apparatus and which is thought to interact with ADP-ribosylation factor 1 (ARF1). The encoded protein likely promotes hydrolysis of ARF1-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to phospholipids. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000242247 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054277 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zhang C, Yu Y, Zhang S, Liu M, Xing G, Wei H, Bi J, Liu X, Zhou G, Dong C, Hu Z, Zhang Y, Luo L, Wu C, Zhao S, He F (Jul 2000). "Characterization, chromosomal assignment, and tissue expression of a novel human gene belonging to the ARF GAP family". Genomics. 63 (3): 400–8. doi:10.1006/geno.1999.6095. PMID 10704287.
  6. ^ Liu X, Zhang C, Xing G, Chen Q, He F (Feb 2001). "Functional characterization of novel human ARFGAP3". FEBS Lett. 490 (1–2): 79–83. doi:10.1016/S0014-5793(01)02134-2. PMID 11172815. S2CID 34808599.
  7. ^ a b "Entrez Gene: ARFGAP3 ADP-ribosylation factor GTPase activating protein 3".

External links

Further reading

  • Matoba R, Okubo K, Hori N, et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene. 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID 8076819.
  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating human gene annotation: a second-generation analysis of chromosome 22". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMC 430954. PMID 12529303.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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  • 2crw: Solution structure of the ArfGap domain of ADP-ribosylation factor GTPaseactivating protein 3 (ArfGap 3)
    2crw: Solution structure of the ArfGap domain of ADP-ribosylation factor GTPaseactivating protein 3 (ArfGap 3)


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