AP3S1

Protein-coding gene in the species Homo sapiens
AP3S1
Identifiers
AliasesAP3S1, CLAPS3, Sigma3A, adaptor related protein complex 3 sigma 1 subunit, adaptor related protein complex 3 subunit sigma 1
External IDsOMIM: 601507; MGI: 1337062; HomoloGene: 4254; GeneCards: AP3S1; OMA:AP3S1 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for AP3S1
Genomic location for AP3S1
Band5q22.3-q23.1Start115,841,481 bp[1]
End115,914,081 bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for AP3S1
Genomic location for AP3S1
Band18|18 CStart46,874,943 bp[2]
End46,923,893 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • hippocampus proper

  • superior frontal gyrus

  • anterior cingulate cortex

  • amygdala

  • dorsolateral prefrontal cortex

  • nucleus accumbens

  • ascending aorta

  • right coronary artery

  • tibial arteries
Top expressed in
  • ganglionic eminence

  • thymus

  • white adipose tissue

  • granulocyte

  • neural tube

  • ileum

  • mesencephalon

  • ventricular zone

  • jejunum

  • ovary
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • transporter activity
Cellular component
  • AP-3 adaptor complex
  • membrane coat
  • Golgi apparatus
  • AP-type membrane coat adaptor complex
  • transport vesicle
  • cytoplasmic vesicle membrane
  • intracellular membrane-bounded organelle
  • membrane
  • cytoplasmic vesicle
  • axon cytoplasm
Biological process
  • anterograde axonal transport
  • protein transport
  • insulin receptor signaling pathway
  • anterograde synaptic vesicle transport
  • intracellular protein transport
  • vesicle-mediated transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1176

11777

Ensembl

ENSG00000177879

ENSMUSG00000024480

UniProt

Q92572

Q9DCR2

RefSeq (mRNA)
NM_001002924
NM_001284
NM_001318090
NM_001318091
NM_001318093

NM_001318094

NM_009681
NM_001303015

RefSeq (protein)
NP_001002924
NP_001275
NP_001305019
NP_001305020
NP_001305022

NP_001305023
NP_001351048
NP_001351049
NP_001351051

NP_001289944
NP_033811

Location (UCSC)Chr 5: 115.84 – 115.91 MbChr 18: 46.87 – 46.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

AP-3 complex subunit sigma-1 is a protein that in humans is encoded by the AP3S1 gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000177879 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024480 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Watanabe TK, Shimizu F, Nagata M, Takaichi A, Fujiwara T, Nakamura Y, Takahashi E, Hirai Y (Sep 1996). "Cloning, expression pattern and mapping to 12p 13.2 --> p13.1 of CLAPS3, a gene encoding a novel clathrin-adaptor small chain". Cytogenetics and Cell Genetics. 73 (3): 214–7. doi:10.1159/000134341. PMID 8697810.
  6. ^ Dell'Angelica EC, Ohno H, Ooi CE, Rabinovich E, Roche KW, Bonifacino JS (March 1997). "AP-3: an adaptor-like protein complex with ubiquitous expression". The EMBO Journal. 16 (5): 917–28. doi:10.1093/emboj/16.5.917. PMC 1169692. PMID 9118953.
  7. ^ "Entrez Gene: AP3S1 adaptor-related protein complex 3, sigma 1 subunit".

External links

Further reading

  • Simpson F, Peden AA, Christopoulou L, Robinson MS (May 1997). "Characterization of the adaptor-related protein complex, AP-3". The Journal of Cell Biology. 137 (4): 835–45. doi:10.1083/jcb.137.4.835. PMC 2139840. PMID 9151686.
  • VanRenterghem B, Morin M, Czech MP, Heller-Harrison RA (November 1998). "Interaction of insulin receptor substrate-1 with the sigma3A subunit of the adaptor protein complex-3 in cultured adipocytes". The Journal of Biological Chemistry. 273 (45): 29942–9. doi:10.1074/jbc.273.45.29942. PMID 9792713.
  • Rodionov DG, Höning S, Silye A, Kongsvik TL, von Figura K, Bakke O (December 2002). "Structural requirements for interactions between leucine-sorting signals and clathrin-associated adaptor protein complex AP3". The Journal of Biological Chemistry. 277 (49): 47436–43. doi:10.1074/jbc.M207149200. PMID 12370188.
  • Nie Z, Boehm M, Boja ES, Vass WC, Bonifacino JS, Fales HM, Randazzo PA (September 2003). "Specific regulation of the adaptor protein complex AP-3 by the Arf GAP AGAP1". Developmental Cell. 5 (3): 513–21. doi:10.1016/S1534-5807(03)00234-X. PMID 12967569.
  • Salazar G, Love R, Werner E, Doucette MM, Cheng S, Levey A, Faundez V (February 2004). "The zinc transporter ZnT3 interacts with AP-3 and it is preferentially targeted to a distinct synaptic vesicle subpopulation". Molecular Biology of the Cell. 15 (2): 575–87. doi:10.1091/mbc.E03-06-0401. PMC 329249. PMID 14657250.
  • Lefrançois S, Janvier K, Boehm M, Ooi CE, Bonifacino JS (October 2004). "An ear-core interaction regulates the recruitment of the AP-3 complex to membranes". Developmental Cell. 7 (4): 619–25. doi:10.1016/j.devcel.2004.08.009. PMID 15469849.


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