AP2S1

Protein-coding gene in the species Homo sapiens
AP2S1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2JKR, 2JKT, 2VGL, 2XA7, 4UQI, 4NEE

Identifiers
AliasesAP2S1, AP17, CLAPS2, FBH3, FBHOk, HHC3, adaptor related protein complex 2 sigma 1 subunit, adaptor related protein complex 2 subunit sigma 1
External IDsOMIM: 602242; MGI: 2141861; HomoloGene: 3001; GeneCards: AP2S1; OMA:AP2S1 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for AP2S1
Genomic location for AP2S1
Band19q13.32Start46,838,136 bp[1]
End46,850,846 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for AP2S1
Genomic location for AP2S1
Band7|7 A2Start16,472,335 bp[2]
End16,483,219 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • stromal cell of endometrium

  • right adrenal gland

  • right frontal lobe

  • mucosa of transverse colon

  • human penis

  • right adrenal cortex

  • left adrenal gland

  • left adrenal cortex

  • prefrontal cortex

  • cingulate gyrus
Top expressed in
  • dentate gyrus of hippocampal formation granule cell

  • primary visual cortex

  • superior frontal gyrus

  • granulocyte

  • facial motor nucleus

  • neural tube

  • ventricular zone

  • yolk sac

  • lip

  • stroma of bone marrow
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • transporter activity
  • clathrin adaptor activity
  • protein binding
Cellular component
  • endocytic vesicle membrane
  • cytosol
  • clathrin-coated endocytic vesicle membrane
  • membrane
  • plasma membrane
  • endolysosome membrane
  • membrane coat
  • clathrin-coated pit
  • AP-2 adaptor complex
  • clathrin-coated endocytic vesicle
  • intracellular membrane-bounded organelle
Biological process
  • regulation of endocytosis
  • endocytosis
  • antigen processing and presentation of exogenous peptide antigen via MHC class II
  • ephrin receptor signaling pathway
  • mitigation of host defenses by virus
  • clathrin-dependent endocytosis
  • clathrin coat assembly
  • protein transport
  • intracellular protein transport
  • vesicle-mediated transport
  • microtubule-based movement
  • Wnt signaling pathway, planar cell polarity pathway
  • membrane organization
  • low-density lipoprotein particle receptor catabolic process
  • low-density lipoprotein particle clearance
  • transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1175

232910

Ensembl

ENSG00000042753

ENSMUSG00000008036

UniProt

P53680

P62743

RefSeq (mRNA)

NM_001301076
NM_001301078
NM_001301081
NM_004069
NM_021575

NM_198613

RefSeq (protein)

NP_001288005
NP_001288007
NP_001288010
NP_004060
NP_067586

NP_941015

Location (UCSC)Chr 19: 46.84 – 46.85 MbChr 7: 16.47 – 16.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

AP-2 complex subunit sigma is a protein that in humans is encoded by the AP2S1 gene.[5][6][7]

One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing has been observed in this gene and results in two known transcripts.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000042753 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000008036 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Winterpacht A, Endele S, Enklaar T, Fuhry M, Zabel B (Mar 1997). "Human CLAPS2 encoding AP17, a small chain of the clathrin-associated protein complex: cDNA cloning and chromosomal assignment to 19q13.2→q13.3". Cytogenet Cell Genet. 75 (2–3): 132–5. doi:10.1159/000134463. PMID 9040778.
  6. ^ Holzmann K, Poltl A, Sauermann G (Nov 1998). "A novel spliced transcript of human CLAPS2 encoding a protein alternative to clathrin adaptor protein AP17". Gene. 220 (1–2): 39–44. doi:10.1016/S0378-1119(98)00406-5. PMID 9767099.
  7. ^ a b "Entrez Gene: AP2S1 adaptor-related protein complex 2, sigma 1 subunit".

Further reading

  • Pearse BM, Smith CJ, Owen DJ (2000). "Clathrin coat construction in endocytosis". Curr. Opin. Struct. Biol. 10 (2): 220–8. doi:10.1016/S0959-440X(00)00071-3. PMID 10753805.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Byland R, Vance PJ, Hoxie JA, Marsh M (2007). "A Conserved Dileucine Motif Mediates Clathrin and AP-2–dependent Endocytosis of the HIV-1 Envelope Protein". Mol. Biol. Cell. 18 (2): 414–25. doi:10.1091/mbc.E06-06-0535. PMC 1783771. PMID 17108326.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Batonick M, Favre M, Boge M, et al. (2006). "Interaction of HIV-1 Gag with the clathrin-associated adaptor AP-2". Virology. 342 (2): 190–200. doi:10.1016/j.virol.2005.08.001. PMID 16139856.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Vendeville A, Rayne F, Bonhoure A, et al. (2005). "HIV-1 Tat Enters T Cells Using Coated Pits before Translocating from Acidified Endosomes and Eliciting Biological Responses". Mol. Biol. Cell. 15 (5): 2347–60. doi:10.1091/mbc.E03-12-0921. PMC 404028. PMID 15020715.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Collins BM, McCoy AJ, Kent HM, et al. (2002). "Molecular architecture and functional model of the endocytic AP2 complex". Cell. 109 (4): 523–35. doi:10.1016/S0092-8674(02)00735-3. PMID 12086608. S2CID 483953.
  • Berlioz-Torrent C, Shacklett BL, Erdtmann L, et al. (1999). "Interactions of the Cytoplasmic Domains of Human and Simian Retroviral Transmembrane Proteins with Components of the Clathrin Adaptor Complexes Modulate Intracellular and Cell Surface Expression of Envelope Glycoproteins". J. Virol. 73 (2): 1350–61. doi:10.1128/JVI.73.2.1350-1361.1999. PMC 103959. PMID 9882340.
  • Page LJ, Robinson MS (1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". J. Cell Biol. 131 (3): 619–30. doi:10.1083/jcb.131.3.619. PMC 2120623. PMID 7593184.
  • Kirchhausen T, Nathanson KL, Matsui W, et al. (1989). "Structural and functional division into two domains of the large (100- to 115-kDa) chains of the clathrin-associated protein complex AP-2". Proc. Natl. Acad. Sci. U.S.A. 86 (8): 2612–6. Bibcode:1989PNAS...86.2612K. doi:10.1073/pnas.86.8.2612. PMC 286967. PMID 2495531.
  • Kirchhausen T, Davis AC, Frucht S, et al. (1991). "AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast". J. Biol. Chem. 266 (17): 11153–7. doi:10.1016/S0021-9258(18)99141-6. PMID 2040623.
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