AP1AR

Protein-coding gene in the species Homo sapiens
AP1AR
Identifiers
AliasesAP1AR, 2C18, C4orf16, GBAR, gamma-BAR, PRO0971, adaptor related protein complex 1 associated regulatory protein
External IDsOMIM: 610851; MGI: 2384822; HomoloGene: 10236; GeneCards: AP1AR; OMA:AP1AR - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for AP1AR
Genomic location for AP1AR
Band4q25Start112,231,740 bp[1]
End112,273,110 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for AP1AR
Genomic location for AP1AR
Band3|3 G2Start127,600,656 bp[2]
End127,631,172 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • ganglionic eminence

  • jejunal mucosa

  • rectum

  • monocyte

  • testicle

  • ventricular zone

  • mucosa of sigmoid colon

  • stromal cell of endometrium

  • islet of Langerhans
Top expressed in
  • trigeminal ganglion

  • epithelium of small intestine

  • conjunctival fornix

  • vestibular membrane of cochlear duct

  • dorsal striatum

  • Ileal epithelium

  • primitive streak

  • corneal stroma

  • entorhinal cortex

  • vestibular sensory epithelium
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • kinesin binding
  • AP-1 adaptor complex binding
Cellular component
  • late endosome
  • Golgi apparatus
  • early endosome
  • transport vesicle
  • cytosol
  • endosome
Biological process
  • protein transport
  • negative regulation of cell motility
  • negative regulation of substrate adhesion-dependent cell spreading
  • regulation of Arp2/3 complex-mediated actin nucleation
  • negative regulation of receptor recycling
  • vesicle targeting, trans-Golgi to endosome
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55435

211556

Ensembl

ENSG00000138660

ENSMUSG00000074238

UniProt

Q63HQ0

n/a

RefSeq (mRNA)

NM_001128426
NM_018569

NM_145964
NM_001346718

RefSeq (protein)

NP_001121898
NP_061039

n/a

Location (UCSC)Chr 4: 112.23 – 112.27 MbChr 3: 127.6 – 127.63 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

AP-1 complex-associated regulatory protein (Gamma1-adaptin brefeldin A resistance protein) is a protein that in humans is encoded by the AP1AR gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138660 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074238 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Neubrand VE, Will RD, Mobius W, Poustka A, Wiemann S, Schu P, Dotti CG, Pepperkok R, Simpson JC (Apr 2005). "Gamma-BAR, a novel AP-1-interacting protein involved in post-Golgi trafficking". EMBO J. 24 (6): 1122–33. doi:10.1038/sj.emboj.7600600. PMC 556403. PMID 15775984.
  6. ^ "Entrez Gene: C4orf16 chromosome 4 open reading frame 16".

External links

Further reading

  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.


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