ABCC10

Protein-coding gene in the species Homo sapiens
ABCC10
Identifiers
AliasesABCC10, EST182763, MRP7, SIMRP7, ATP binding cassette subfamily C member 10
External IDsOMIM: 612509; MGI: 2386976; HomoloGene: 58616; GeneCards: ABCC10; OMA:ABCC10 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for ABCC10
Genomic location for ABCC10
Band6p21.1Start43,427,366 bp[1]
End43,450,427 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for ABCC10
Genomic location for ABCC10
Band17|17 CStart46,614,147 bp[2]
End46,639,278 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right hemisphere of cerebellum

  • granulocyte

  • right ovary

  • pituitary gland

  • anterior pituitary

  • right adrenal cortex

  • apex of heart

  • left ovary

  • epithelium of nasopharynx

  • right frontal lobe
Top expressed in
  • substantia nigra

  • trigeminal ganglion

  • yolk sac

  • spermatocyte

  • neural layer of retina

  • right kidney

  • duodenum

  • proximal tubule

  • ascending aorta

  • secondary oocyte
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • nucleotide binding
  • ATPase activity
  • ATP binding
  • ATPase-coupled inorganic anion transmembrane transporter activity
  • ATPase-coupled transmembrane transporter activity
Cellular component
  • integral component of membrane
  • lysosomal membrane
  • plasma membrane
  • membrane
  • integral component of plasma membrane
Biological process
  • transmembrane transport
  • transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

89845

224814

Ensembl

ENSG00000124574

ENSMUSG00000032842

UniProt

Q5T3U5

Q8R4P9

RefSeq (mRNA)

NM_001198934
NM_033450
NM_001350518

NM_145140
NM_170680
NM_001347396

RefSeq (protein)

NP_001185863
NP_258261
NP_001337447

NP_001334325
NP_660122
NP_733780

Location (UCSC)Chr 6: 43.43 – 43.45 MbChr 17: 46.61 – 46.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Multidrug resistance-associated protein 7 is a protein that in humans is encoded by the ABCC10 gene.[5][6]

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described.[6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124574 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032842 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Allikmets R, Gerrard B, Hutchinson A, Dean M (Feb 1997). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database". Hum Mol Genet. 5 (10): 1649–55. doi:10.1093/hmg/5.10.1649. PMID 8894702.
  6. ^ a b "Entrez Gene: ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10".

Further reading

  • Hopper E, Belinsky MG, Zeng H, et al. (2001). "Analysis of the structure and expression pattern of MRP7 (ABCC10), a new member of the MRP subfamily". Cancer Lett. 162 (2): 181–91. doi:10.1016/S0304-3835(00)00646-7. PMID 11146224.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Chen ZS, Hopper-Borge E, Belinsky MG, et al. (2003). "Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10)". Mol. Pharmacol. 63 (2): 351–8. doi:10.1124/mol.63.2.351. PMID 12527806. S2CID 26642179.
  • Kao HH, Chang MS, Cheng JF, Huang JD (2003). "Genomic structure, gene expression, and promoter analysis of human multidrug resistance-associated protein 7". J. Biomed. Sci. 10 (1): 98–110. doi:10.1159/000068078. PMID 12566991. S2CID 202649323.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404. S2CID 4423608.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. S2CID 21903526.
  • Hopper-Borge E, Chen ZS, Shchaveleva I, et al. (2004). "Analysis of the drug resistance profile of multidrug resistance protein 7 (ABCC10): resistance to docetaxel". Cancer Res. 64 (14): 4927–30. doi:10.1158/0008-5472.CAN-03-3111. PMID 15256465. S2CID 6933602.
  • Wooden SL, Kalb SR, Cotter RJ, Soloski MJ (2005). "Cutting edge: HLA-E binds a peptide derived from the ATP-binding cassette transporter multidrug resistance-associated protein 7 and inhibits NK cell-mediated lysis". J. Immunol. 175 (3): 1383–7. doi:10.4049/jimmunol.175.3.1383. PMID 16034073. S2CID 22554947.
  • Naramoto H, Uematsu T, Uchihashi T, et al. (2007). "Multidrug resistance-associated protein 7 expression is involved in cross-resistance to docetaxel in salivary gland adenocarcinoma cell lines". Int. J. Oncol. 30 (2): 393–401. doi:10.3892/ijo.30.2.393 (inactive 31 January 2024). PMID 17203221.{{cite journal}}: CS1 maint: DOI inactive as of January 2024 (link)

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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